Universität zu Köln

Lundt, Andreas, Seidel, Robin, Soos, Julien, Henseler, Christina, Mueller, Ralf, Bakki, Maheshwar, Arshaad, Muhammad Imran, Ehninger, Dan, Hescheler, Juergen, Sachinidis, Agapios, Broich, Karl, Wormuth, Carola, Papazoglou, Anna and Weiergraeber, Marco (2019). Ca(v)3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System. Neuroscience, 409. S. 81 - 101. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7544

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Abstract

Voltage-gated Ca2+ channels (VGCCs) play key roles in auditory perception and information processing within the inner ear and brainstem. Pharmacological inhibition of low voltage-activated (LVA) T-type Ca2+ channels is related to both age- and noise induced hearing loss in experimental animals and may represent a promising approach to the treatment of auditory impairment of various etiologies. Within the LVA Ca2+ channel subgroup, Ca(v)3.2 is the most prominently expressed T-type channel entity in the cochlea and auditory brainstem. Thus, we performed a complete gender specific click and tone burst based auditory brainstem response (ABR) analysis of Ca(v)3.2(+/-) and Ca(v)3.2(-/-) mice, including i.a. temporal progression in hearing loss, amplitude growth function and wave latency analysis as well as a cochlear qPCR based evaluation of other VGCCs transcripts. Our results, based on a self-programmed automated wavelet approach, demonstrate that both heterozygous and Ca(v)3.2 null mutant mice exhibit age-dependent increases in hearing thresholds at 5 months of age. In addition, complex alterations in WI-IV amplitudes and latencies were detected that were not attributable to alterations in the expression of other VGCCs in the auditory tract. Our results clearly demonstrate the important physiological role of Ca(v)3.2 VGCCs in the spatiotemporal organization of auditory processing in young adult mice and suggest potential pharmacological targets for interventions in the future. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IBRO.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lundt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Robin UNSPECIFIED UNSPECIFIED UNSPECIFIED Soos, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Henseler, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Bakki, Maheshwar UNSPECIFIED UNSPECIFIED UNSPECIFIED Arshaad, Muhammad Imran UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehninger, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachinidis, Agapios UNSPECIFIED UNSPECIFIED UNSPECIFIED Broich, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Wormuth, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Papazoglou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiergraeber, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137756
DOI:	10.1016/j.neuroscience.2019.04.024
Journal or Publication Title:	Neuroscience
Volume:	409
Page Range:	S. 81 - 101
Date:	2019
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7544
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPIRAL GANGLION NEURONS; SENSORINEURAL HEARING-LOSS; CA(V)1.3 CA2+ CHANNELS; BRAIN-STEM RESPONSES; CARDIOVASCULAR-DISEASE; THERAPEUTIC FUNCTIONS; MOUSE MODELS; MICE; DYSFUNCTION; EXPRESSION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13775