Universität zu Köln

Held, Torsten ORCID: 0000-0002-1131-1950, Klemmer, Daniel and Laessig, Michael (2019). Survival of the simplest in microbial evolution. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The evolution of microbial and viral organisms often generates clonal interference, a mode of competition between genetic clades within a population. Here we show how interference impacts systems biology by constraining genetic and phenotypic complexity. Our analysis uses biophysically grounded evolutionary models for molecular phenotypes, such as fold stability and enzymatic activity of genes. We find a generic mode of phenotypic interference that couples the function of individual genes and the population's global evolutionary dynamics. Biological implications of phenotypic interference include rapid collateral system degradation in adaptation experiments and long-term selection against genome complexity: each additional gene carries a cost proportional to the total number of genes. Recombination above a threshold rate can eliminate this cost, which establishes a universal, biophysically grounded scenario for the evolution of sex. In a broader context, our analysis suggests that the systems biology of microbes is strongly intertwined with their mode of evolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Held, Torsten UNSPECIFIED orcid.org/0000-0002-1131-1950 UNSPECIFIED Klemmer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Laessig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138101
DOI:	10.1038/s41467-019-10413-8
Journal or Publication Title:	Nat. Commun.
Volume:	10
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institute for Theoretical Physics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUTATION-SELECTION BALANCE; STABILIZING SELECTION; BENEFICIAL MUTATIONS; SEXUAL POPULATIONS; ADAPTIVE EVOLUTION; GENE-EXPRESSION; FITNESS; ADAPTATION; DYNAMICS; BINDING Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13810