Universität zu Köln

Siedek, Florian, Yeo, Sin Yuin, Heijman, Edwin, Grinstein, Olga, Bratke, Grischa, Heneweer, Carola, Puesken, Michael, Persigehl, Thorsten, Maintz, David and Gruell, Holger (2019). Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2). Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr., 191 (6). S. 531 - 540. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-9010

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Abstract

Background High-intensity focused ultrasound (HIFU) allows noninvasive heating of deep-seated tissues. Guidance under magnetic resonance imaging (MR-HIFU) offers spatial targeting based on anatomical MR images as well as MR-based near-real-time temperature maps. Temperature feedback allows delivery of a well-defined thermal dose enabling new applications such as the ablation of malignant tissue. Methods Peer-reviewed publications on MR-HIFU were studied and are summarized in this review. Literature was restricted to applications in oncology. Results Several MR-HIFU-based applications for the treatment of malignant diseases are currently part of clinical trials or translational research. Recent trials regarding the treatment of prostate cancer with MR-HIFU have already shown this to be a safe and patient-friendly method. For the treatment of breast cancer and malignancies within abdominal organs, MR-HIFU has been applied so far only in proof of concept studies. Conclusion MR-HIFU is currently being investigated for the ablative treatment of malignant tissue in a variety of oncological applications. For example, the transrectal as well as transurethral ablation of prostate cancer using MR-HIFU was shown to be a patient-friendly, safe alternative to other local treatment options with low side effects. Key points: MR guidance offers high soft tissue contrast for treatment planning, near-real-time temperature monitoring, and post-interventional therapy evaluation. Special HIFU transducers and technological solutions are available for the treatment of e.g. prostate cancer, breast cancer or abdominal malignancies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Yeo, Sin Yuin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heijman, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Grinstein, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Bratke, Grischa UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneweer, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Puesken, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruell, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138734
DOI:	10.1055/a-0817-5686
Journal or Publication Title:	Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr.
Volume:	191
Number:	6
Page Range:	S. 531 - 540
Date:	2019
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-9010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCALIZED PROSTATE-CANCER; RADICAL PROSTATECTOMY; BREAST-CANCER; FOCAL THERAPY; ABLATION; LIVER; FEASIBILITY; EXPERIENCE; SURVIVAL; TISSUE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13873