Universität zu Köln

Zittermann, Armin, Ernst, Jana B., Prokop, Sylvana, Fuchs, Uwe, Dreier, Jens, Kuhn, Joachim, Knabbe, Cornelius, Borgermann, Jochen, Berthold, Heiner K., Pilz, Stefan ORCID: 0000-0002-7959-1311, Gouni-Berthold, Ioanna and Gummert, Jan F. (2019). Daily Supplementation with 4000 IU Vitamin D3 for Three Years Does Not Modify Cardiovascular Risk Markers in Patients with Advanced Heart Failure: The Effect of Vitamin D on Mortality in Heart Failure Trial. Ann. Nutr. Metab., 74 (1). S. 62 - 69. BASEL: KARGER. ISSN 1421-9697

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Abstract

Background/Aims: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease. Methods: We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations <75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D-3 supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. Results: Lipid parameters, the percentage of patients with dyslipoproteinemia, and VC markers did not differ significantly between groups at study termination (p values: 0.395-0.939). Like-wise, vitamin D achieved no significant treatment effect on these markers in subgroup analyses in patients with 25OHD concentrations <30 nmol/L, nonusers of lipid-lowering drugs, or diabetic patients (p values: 0.245-0.998). Conclusion: Our data indicate that vitamin D does not improve the lipid profile and does not influence the calcification inhibitors fetuin-A and non-phosphorylated undercarboxylated MGP in patients with advanced heart failure. (C) 2018 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zittermann, Armin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Jana B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Sylvana UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreier, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Knabbe, Cornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgermann, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Heiner K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilz, Stefan UNSPECIFIED orcid.org/0000-0002-7959-1311 UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Gummert, Jan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139611
DOI:	10.1159/000495662
Journal or Publication Title:	Ann. Nutr. Metab.
Volume:	74
Number:	1
Page Range:	S. 62 - 69
Date:	2019
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9697
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC KIDNEY-DISEASE; VASCULAR CALCIFICATION; LIPID PROFILE; METAANALYSIS Multiple languages Endocrinology & Metabolism; Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13961