Universität zu Köln

Vachiery, Jean-Luc, Tedford, Ryan J., Rosenkranz, Stephan, Palazzini, Massimiliano, Lang, Irene, Guazzi, Marco ORCID: 0000-0002-8456-609X, Coghlan, Gerry, Chazova, Irina and De Marco, Teresa (2019). Pulmonary hypertension due to left heart disease. Eur. Resp. J., 53 (1). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1399-3003

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Abstract

Pulmonary hypertension (PH) is frequent in left heart disease (LHD), as a consequence of the underlying condition. Significant advances have occurred over the past 5 years since the 5th World Symposium on Pulmonary Hypertension in 2013, leading to a better understanding of PH-LHD, challenges and gaps in evidence. PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH. Based on the latest evidence, we propose a new haemodynamic definition for PH due to LHD and a three-step pragmatic approach to differential diagnosis. This includes the identification of a specific left heart phenotype and a non-invasive probability of PH-LHD. Invasive confirmation of PH-LHD is based on the accurate measurement of pulmonary arterial wedge pressure and, in patients with high probability, provocative testing to clarify the diagnosis. Finally, recent clinical trials did not demonstrate a benefit in treating PH due to LHD with pulmonary arterial hypertension-approved therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vachiery, Jean-Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED Tedford, Ryan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Palazzini, Massimiliano UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Guazzi, Marco UNSPECIFIED orcid.org/0000-0002-8456-609X UNSPECIFIED Coghlan, Gerry UNSPECIFIED UNSPECIFIED UNSPECIFIED Chazova, Irina UNSPECIFIED UNSPECIFIED UNSPECIFIED De Marco, Teresa UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139765
DOI:	10.1183/13993003.01897-2018
Journal or Publication Title:	Eur. Resp. J.
Volume:	53
Number:	1
Date:	2019
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1399-3003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRESERVED EJECTION FRACTION; ARTERY WEDGE PRESSURE; GUANYLATE-CYCLASE STIMULATOR; RIGHT-VENTRICULAR FUNCTION; EXERCISE HEMODYNAMICS; PRE-CAPILLARY; ECHOCARDIOGRAPHIC PREDICTION; DIASTOLIC DYSFUNCTION; VASCULAR-RESISTANCE; FAILURE PATIENTS Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13976