Universität zu Köln

Alidousty, Christina, Baar, Till, Heydt, Carina, Wagener-Ryczek, Svenja, Kron, Anna, Wolf, Juergen, Buettner, Reinhard and Schultheis, Anne Maria (2019). Advance of theragnosis biomarkers in lung cancer: from clinical to molecular pathology and biology. J. Thorac. Dis., 11. S. S3 - 6. SHATIN: AME PUBL CO. ISSN 2077-6624

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Abstract

One distinct molecular subtype of non-small cell lung cancer (NSCLC) is defined by rearrangement of the anaplastic lymphoma kinase (ALK). The increasing knowledge over the last years has enabled the continuous improvement of ALK inhibitors; however, resistance in these patients remains a major concern. In this review, we summarize recent findings in ALK+-adenocarcinoma of the lung, highlighting the role of TP53 mutations in this specific cancer type and suggest new diagnostic strategies for the future, in order to improve patient's outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Alidousty, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Baar, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Heydt, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener-Ryczek, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kron, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultheis, Anne Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139991
DOI:	10.21037/jtd.2018.12.03
Journal or Publication Title:	J. Thorac. Dis.
Volume:	11
Page Range:	S. S3 - 6
Date:	2019
Publisher:	AME PUBL CO
Place of Publication:	SHATIN
ISSN:	2077-6624
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANAPLASTIC LYMPHOMA KINASE; CRIZOTINIB RESISTANCE; PRACTICE GUIDELINES; TARGETED THERAPY; GROWTH-FACTOR; ALK; MUTATIONS; RECEPTOR; IDENTIFICATION; DIAGNOSIS Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13999