Universität zu Köln

Erren, Thomas C. and Lewis, Philip (2019). Hypothesis: ubiquitous circadian disruption can cause cancer. Eur. J. Epidemiol., 34 (1). S. 1 - 5. DORDRECHT: SPRINGER. ISSN 1573-7284

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Abstract

Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogenic in 2007. In the following decade, epidemiological studies into causal concepts associated with circadian disruption were inconclusive. Unappreciated complexity with an exclusive focus on shift-work, light-at-night, sleep, and melatonin in regard to circadian disruption may be accountable. With compelling non-epidemiological evidence, we posit that ubiquitous circadian disruption causes cancer and, moreover, that this is unexplored epidemiologically. This hypothesis offers a novel explanation why numerous studies in shift-workers evince inconsistent results: If circadian disruption is a ubiquitous causal phenomenon, confining assessments to the workplace, ignoring circadian disruption at play, and potential misclassification of who' is when' and how much' exposed to circadian disruption may disallow detecting the existence and magnitude of cancer risks. The rationale herein provides plausible explanations for previous observations and makes falsifiable predictions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140348
DOI:	10.1007/s10654-018-0469-6
Journal or Publication Title:	Eur. J. Epidemiol.
Volume:	34
Number:	1
Page Range:	S. 1 - 5
Date:	2019
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-7284
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER; LIGHT; SLEEP; CHRONODISRUPTION; MISALIGNMENT Multiple languages Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14034