Universität zu Köln

Bredart, Anne, Kop, Jean-Luc, Antoniou, Antonis C., Cunningham, Alex P., De Pauw, Antoine, Tischkowitz, Marc ORCID: 0000-0002-7880-0628, Ehrencrona, Hans ORCID: 0000-0002-5589-3622, Schmidt, Marjanka K., Dolbeault, Sylvie, Rhiem, Kerstin, Easton, Douglas F., Devilee, Peter, Stoppa-Lyonnet, Dominique and Schmutlzer, Rita (2019). Clinicians' use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey. J. Commun. Genet., 10 (1). S. 61 - 72. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1868-6001

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Abstract

The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC risk assessment tools and respondents' perceived importance of BC risk factors. Respondents (N=443) varied in age, country and clinical seniority but comprised mainly genetics health professionals (82%) and BWA users (93%). Oncology professionals perceived reproductive, hormonal (exogenous) and lifestyle BC risk factors as more important in BC risk assessment compared to genetics professionals (p values <0.05 to 0.0001). BWA was used more frequently by respondents who gave high weight to breast tumour pathology and low weight to personal BC history as BC risk factors. BWA use was positively related to the weight given to hormonal BC risk factors. The importance attributed to lifestyle and BMI BC risk factors was not associated with the use of BWA or any of the other tools. Next version of the BWA encompassing additional BC risk factors will facilitate more comprehensive BC risk assessment in genetics and oncology practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bredart, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kop, Jean-Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED Antoniou, Antonis C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cunningham, Alex P. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Pauw, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Tischkowitz, Marc UNSPECIFIED orcid.org/0000-0002-7880-0628 UNSPECIFIED Ehrencrona, Hans UNSPECIFIED orcid.org/0000-0002-5589-3622 UNSPECIFIED Schmidt, Marjanka K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolbeault, Sylvie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Easton, Douglas F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Devilee, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoppa-Lyonnet, Dominique UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutlzer, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140385
DOI:	10.1007/s12687-018-0362-8
Journal or Publication Title:	J. Commun. Genet.
Volume:	10
Number:	1
Page Range:	S. 61 - 72
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1868-6001
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MANCHESTER SCORING SYSTEM; EXISTING MODELS; BOADICEA; PREDICTION; BRCA1; SUSCEPTIBILITY; VALIDATION; MUTATION; PROBABILITIES; WOMEN Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14038