Universität zu Köln

Kondylis, Vangelis ORCID: 0000-0002-6970-8731 and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2019). RIP Kinases in Liver Cell Death, Inflammation and Cancer. Trends Mol. Med, 25 (1). S. 47 - 64. OXFORD: ELSEVIER SCI LTD. ISSN 1471-499X

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Abstract

Cell death is intrinsically linked to inflammatory liver disease and cancer development. Recent genetic studies have suggested that receptor-interacting protein kinase (RIPK) 1 is implicated in liver disease pathogenesis by regulating caspase-dependent hepatocyte apoptosis induced by tumor necrosis factor (TNF) or other stimuli. In contrast, the contribution of caspase-independent RIPK3/mixed lineage kinase like (MLKL)-mediated hepatocyte necroptosis remains debatable. Hepatocyte apoptosis depends on the balance between RIPK1 prosurvival scaffolding functions and its kinase-activity-mediated proapoptotic function. Several regulatory steps promote the prosurvival role of RIPK1, including phosphorylation and ubiquitination of RIPK1 itself and other molecules involved in RIPK1 signaling. Pharmacological inhibition of liver damage by targeting RIPK1 signaling emerges as a potential therapeutic strategy to prevent chronic liver inflammation and hepatocarcinogenesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kondylis, Vangelis UNSPECIFIED orcid.org/0000-0002-6970-8731 UNSPECIFIED Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140639
DOI:	10.1016/j.molmed.2018.10.007
Journal or Publication Title:	Trends Mol. Med
Volume:	25
Number:	1
Page Range:	S. 47 - 64
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-499X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; TNF-INDUCED APOPTOSIS; HEPATOCELLULAR-CARCINOMA; HEPATOCYTE APOPTOSIS; ESSENTIAL MODULATOR; PROTECTS MICE; IN-VIVO; NECROPTOSIS; NECROSIS; NEMO Multiple languages Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14063