Universität zu Köln

Ebert, Anne-Karoline, Zwink, Nadine, Jenetzky, Ekkehart ORCID: 0000-0001-5415-8784, Stein, Raimund, Boemers, Thomas M., Lacher, Martin, Fortmann, Caroline, Obermayr, Florian, Fisch, Margit, Mortazawi, Kiarasch, Schmiedeke, Eberhard, Eisenschmidt, Volker, Schaefer, Mattias, Hirsch, Karin, Roesch, Wolfgang H. and Reutter, Heiko (2019). Association Between Exstrophy-epispadias Complex And Congenital Anomalies: A German Multicenter Study. Urology, 123. S. 210 - 220. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1527-9995

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Abstract

OBJECTIVE To further investigate associated anomalies in exstrophy-epispadias complex (EEC) patients con- genital uro-rectal malformations network (CURE-Net) database was systematically screened. In literature the EEC comprises a spectrum of anomalies, mainly occurring isolated without additional congenital defects. Nevertheless, previous epidemiological studies indicated a higher association with renal, anorectal, and lower neurotubular anomalies, which may originate from the same developmental morphogenetic fields. MATERIALS AND METHODS Seventy-three prospectively (born since 2009) and 162 cross-sectional recruited EEC patients (born 1948-2008) were analyzed. Associated anomalies were derived from patient's medical data as well as from a physical examination during a physician's interview, classified according to the international statistical classification of diseases and related health problems and grouped with the London Dysmorphology Database. Descriptive statistical analyses were performed. RESULTS Majority of participants were male (68%) and expressed the classical bladder exstrophy phenotype (71%). Exstrophy variants occurred significantly more often in newborns (21%, P < .0001). Anomalies such as inguinal hernias, skeleton, and joint anomalies were equally present in both groups (P = .65 and P = .67). Heart defects were seen more often in newborns (6%) than in the cross-sectional group (1%; P = .033) and the general German population (1%). In total, 59% of the prospective and 48% of the cross-sectional patients had associated anomalies outside the spectrum (P = .16). CONCLUSION Phenomenological multicenter data confirmed the dimension of associated anomalies inside and outside the EEC spectrum. The detected anomalies are either important in preparing for the primary reconstruction or later in long-term follow-up. Associated anomalies of EEC should be spotlighted during routine check-up in all EEC patients. (C) 2018 Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ebert, Anne-Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwink, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Jenetzky, Ekkehart UNSPECIFIED orcid.org/0000-0001-5415-8784 UNSPECIFIED Stein, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Boemers, Thomas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lacher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fortmann, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermayr, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fisch, Margit UNSPECIFIED UNSPECIFIED UNSPECIFIED Mortazawi, Kiarasch UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmiedeke, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenschmidt, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Mattias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirsch, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Roesch, Wolfgang H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reutter, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140641
DOI:	10.1016/j.urology.2018.05.039
Journal or Publication Title:	Urology
Volume:	123
Page Range:	S. 210 - 220
Date:	2019
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1527-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLADDER EXSTROPHY; DIAGNOSIS; VARIANTS Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14064