Universität zu Köln

Hansen, Max, Brockmann, Michael, Schildgen, Verena and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2019). Human bocavirus is detected in human placenta and aborted tissues. Influenza Other Respir. Viruses, 13 (1). S. 106 - 110. HOBOKEN: WILEY. ISSN 1750-2659

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Abstract

Background To date, four human bocaviruses (HBoV) have been described. The most closely related viruses (bovine and canine parvoviruses) are associated with miscarriage in their hosts. The objective of this retrospective study was to determine the frequency of HBoV DNA in miscarriage. Study Design Tissue samples from 172 patients, in which miscarriage occurred, were included and tested with a published qPCR protocol. Positive PCRs were mutually confirmed by sequencing. Results 43 patients (25%) were positive for HBoV DNA. Of those, the majority of HBoV-positive samples were tissues from miscarriage (placenta: 6; aborted tissue products of conception: 37 specimens). The samples were not paired; either placental or aborted tissue was available. Conclusions The results show that, as long as no animal model is available, the role of HBoV in the occurrence of miscarriage requires additional prospective studies in order to investigate its significance and causal involvements of this pathogen.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hansen, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140662
DOI:	10.1111/irv.12609
Journal or Publication Title:	Influenza Other Respir. Viruses
Volume:	13
Number:	1
Page Range:	S. 106 - 110
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1750-2659
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN PARVOVIRUS; DNA Multiple languages Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14066