Universität zu Köln

Furlan, Raffaello, Heusser, Karsten ORCID: 0000-0002-2571-5585, Minonzio, Maura, Shiffer, Dana, Cairo, Beatrice, Tank, Jens, Jordan, Jens, Diedrich, Andre, Gauger, Peter, Zamuner, Antonio Roberto ORCID: 0000-0002-7480-3047, Dipaola, Franca, Porta, Alberto ORCID: 0000-0002-6720-9824 and Barbic, Franca ORCID: 0000-0002-8283-1988 (2019). Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope. J. Clin. Med., 8 (9). BASEL: MDPI. ISSN 2077-0383

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Abstract

We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor unloading might promote orthostatic pre-syncope. Ten volunteers (32 +/- 6 years) underwent electrocardiogram, beat-to-beat AP, respiratory activity and muscle sympathetic nerve activity (MSNA) recordings while supine (REST) and during 80 degrees head-up tilt (HUT) followed by -10 mmHg stepwise increase of lower body negative pressure until pre-syncope. Cardiac and sympathetic baroreflex sensitivity were quantified. Spectrum analysis of systolic and diastolic AP (SAP and DAP) and calibrated MSNA (cMSNA) variability assessed the low frequency fluctuations (LF, similar to 0.1 Hz) of SAP, DAP and cMSNA variability. The squared coherence function (K-2) quantified the coupling between cMSNA and DAP in the LF band. Analyses were performed while supine, during asymptomatic HUT (T-1) and at pre-syncope onset (T-2). During T-2 we found that: (1) sympathetic baroreceptor modulation was virtually abolished compared to T-1; (2) a progressive decrease in AP was accompanied by a persistent but chaotic sympathetic firing; (3) coupling between cMSNA and AP series at 0.1 Hz was reduced compared to T-1. A negligible sympathetic baroreceptor modulation during pre-syncope might disrupt sympathetic discharge pattern impairing the capability of vessels to constrict and promote pre-syncope.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Furlan, Raffaello UNSPECIFIED UNSPECIFIED UNSPECIFIED Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Minonzio, Maura UNSPECIFIED UNSPECIFIED UNSPECIFIED Shiffer, Dana UNSPECIFIED UNSPECIFIED UNSPECIFIED Cairo, Beatrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Diedrich, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Zamuner, Antonio Roberto UNSPECIFIED orcid.org/0000-0002-7480-3047 UNSPECIFIED Dipaola, Franca UNSPECIFIED UNSPECIFIED UNSPECIFIED Porta, Alberto UNSPECIFIED orcid.org/0000-0002-6720-9824 UNSPECIFIED Barbic, Franca UNSPECIFIED orcid.org/0000-0002-8283-1988 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142192
DOI:	10.3390/jcm8091434
Journal or Publication Title:	J. Clin. Med.
Volume:	8
Number:	9
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEART-RATE-VARIABILITY; NERVE ACTIVITY; BLOOD-PRESSURE; BARORECEPTOR REFLEX; SPECTRAL-ANALYSIS; SHORT-TERM; UP TILT; ABNORMALITIES; MODULATION; PRESYNCOPE Multiple languages Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14219