Rosenkranz, Stephan, Diller, Gerhard-Paul, Dumitrescu, Daniel, Ewer, Ralf, Ghofrani, H. Ardeschir, Gruenig, Ekkehard, Halank, Michael, Held, Matthias, Kaemmerer, Harald, Klose, Hans, Kovacs, Gabor, Konstantinides, Stavros ORCID: 0000-0001-6359-7279, Lang, Irene M., Lange, Tobias J., Leuchte, Hanno, Mayer, Eckhard, Olschewski, Andrea, Olschewski, Horst ORCID: 0000-0002-2834-7466, Olsson, Karen M., Opitz, Christian, Schermuly, Ralph T., Seeger, Werner ORCID: 0000-0003-1946-0894, Wilkens, Heinrike and Hoeper, Marius M. (2019). Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension. Dtsch. Med. Wochenschr., 144 (19). S. 1367 - 1373. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) >= 25mmHg at rest. At the 6th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) >= 3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rosenkranz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diller, Gerhard-PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumitrescu, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewer, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghofrani, H. ArdeschirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruenig, EkkehardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halank, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Held, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaemmerer, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klose, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovacs, GaborUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konstantinides, StavrosUNSPECIFIEDorcid.org/0000-0001-6359-7279UNSPECIFIED
Lang, Irene M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, Tobias J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leuchte, HannoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, EckhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olschewski, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olschewski, HorstUNSPECIFIEDorcid.org/0000-0002-2834-7466UNSPECIFIED
Olsson, Karen M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opitz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schermuly, Ralph T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seeger, WernerUNSPECIFIEDorcid.org/0000-0003-1946-0894UNSPECIFIED
Wilkens, HeinrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeper, Marius M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-142301
DOI: 10.1055/a-0918-3772
Journal or Publication Title: Dtsch. Med. Wochenschr.
Volume: 144
Number: 19
Page Range: S. 1367 - 1373
Date: 2019
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-4413
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYSTEMIC-SCLEROSIS; ARTERIAL-PRESSURE; DIAGNOSIS; MORTALITYMultiple languages
Medicine, General & InternalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14230

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