Universität zu Köln

Petrungaro, Gabriela, Morelli, Luis G. and Uriu, Koichiro (2019). Information flow in the presence of cell mixing and signaling delays during embryonic development. Semin. Cell Dev. Biol., 93. S. 26 - 36. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1084-9521

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Abstract

Embryonic morphogenesis is organized by an interplay between intercellular signaling and cell movements. Both intercellular signaling and cell movement involve multiple timescales. A key timescale for signaling is the time delay caused by preparation of signaling molecules and integration of received signals into cells' internal state. Movement of cells relative to their neighbors may introduce exchange of positions between cells during signaling. When cells change their relative positions in a tissue, the impact of signaling delays on intercellular signaling increases because the delayed information that cells receive may significantly differ from the present state of the tissue. The time it takes to perform a neighbor exchange sets a timescale of cell mixing that may be important for the outcome of signaling. Here we review recent theoretical work on the interplay of timescales between cell mixing and signaling delays adopting the zebrafish segmentation clock as a model system. We discuss how this interplay can lead to spatial patterns of gene expression that could disrupt the normal formation of segment boundaries in the embryo. The effect of cell mixing and signaling delays highlights the importance of theoretical and experimental frameworks to understand collective cellular behaviors arising from the interplay of multiple timescales in embryonic developmental processes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Petrungaro, Gabriela UNSPECIFIED UNSPECIFIED UNSPECIFIED Morelli, Luis G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uriu, Koichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142901
DOI:	10.1016/j.semcdb.2018.09.008
Journal or Publication Title:	Semin. Cell Dev. Biol.
Volume:	93
Page Range:	S. 26 - 36
Date:	2019
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1084-9521
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOVEMENT PROMOTES SYNCHRONIZATION; SOMITE SEGMENTATION CLOCK; WAVE-FRONT MODEL; VERTEBRATE SEGMENTATION; GENE-EXPRESSION; OSCILLATORY EXPRESSION; CHIMERA STATES; TIME DELAYS; ZEBRAFISH; ACTIVATION Multiple languages Cell Biology; Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14290