Universität zu Köln

Wang, Yeli, Koch, Manja ORCID: 0000-0002-4794-4821, di Giuseppe, Romina, Evans, Kirsten, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Nothlings, Ute, Handberg, Aase ORCID: 0000-0001-5719-203X, Jensen, Majken K. and Lieb, Wolfgang (2019). Associations of Plasma CD36 and Body Fat Distribution. J. Clin. Endocrinol. Metab., 104 (9). S. 4016 - 4024. WASHINGTON: ENDOCRINE SOC. ISSN 1945-7197

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Abstract

Context: CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population. Methods: We measured plasma CD36 from 575 participants of the community-based PopGen cohort who underwent MRI to quantify visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver signal intensity (LSI), a proxy for liver fat content. Nonalcoholic fatty liver disease (NAFLD) was defined as LSI >= 3.0 in the absence of high alcohol intake. The relations between plasma CD36 and body mass index (BMI), VAT, SAT, LSI, and NAFLD were evaluated via multivariableadjusted linear and logistic regression analysis. Results: Plasma CD36 concentrations were correlated with BMI (r = 0.11; P= 0.01), SAT (r = 0.16; P< 0.001), and VAT (r= 0.15, P < 0.001) but not with LSI (P= 0.44). In multivariable-adjusted regression models, mean BMI values rose across CD36 quartiles [quartile 1 (Q1), 27.8 kg/m(2); Q4, 28.9 kg/m(2); P-trend = 0.013). Similarly, VAT (Q1, 4.13 dm(3); Q4, 4.71 dm(3); P-trend < 0.001), and SAT (Q1, 7.61 dm(3); Q4, 8.74 dm(3); P-trend < 0.001) rose across CD36 quartiles. Plasma CD36 concentrations were unrelated to LSI (P-trend = 0.36) and NAFLD (P-trend = 0.64). Participants with NAFLD and elevated alanine aminotransferase (ALT), a marker for liver damage, had higher CD36 compared with participants with NAFLD and normal ALT. Conclusions: Higher plasma concentrations of CD36 were associated with greater general and abdominal adiposity but not with liver fat content or NAFLD in this community-based sample. However, plasma CD36 may reflect more severe liver damage in NAFLD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Yeli UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Manja UNSPECIFIED orcid.org/0000-0002-4794-4821 UNSPECIFIED di Giuseppe, Romina UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Nothlings, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Handberg, Aase UNSPECIFIED orcid.org/0000-0001-5719-203X UNSPECIFIED Jensen, Majken K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lieb, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143053
DOI:	10.1210/jc.2019-00368
Journal or Publication Title:	J. Clin. Endocrinol. Metab.
Volume:	104
Number:	9
Page Range:	S. 4016 - 4024
Date:	2019
Publisher:	ENDOCRINE SOC
Place of Publication:	WASHINGTON
ISSN:	1945-7197
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIVER-DISEASE; SOLUBLE CD36; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; NATURAL-HISTORY; ADIPOSE-TISSUE; HIGH SCD36; FOLLOW-UP; MRI Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14305