Universität zu Köln

Schloss, Natalie, Shabes, Polina, Kuniss, Sarah, Willis, Franziska, Treede, Rolf-Detlef, Schmahl, Christian and Baumgaertner, Ulf (2019). Differential perception of sharp pain in patients with borderline personality disorder. Eur. J. Pain, 23 (8). S. 1448 - 1464. HOBOKEN: WILEY. ISSN 1532-2149

Full text not available from this repository.

Abstract

Background Cutting is the most common method of non-suicidal self-injury (NSSI) to reduce inner tension in patients with Borderline Personality Disorder (BPD). Aim of this study was to compare pain perception induced by an incision and by application of a surrogate model for sharp mechanical pain (a non-invasive blade) in BPD. Methods 22 female patients and 20 healthy controls (HC) received a small incision into the volar forearm, a 7s-blade application on the same side, and non-invasive phasic stimuli (pinprick, blade, laser, tactile). Pain intensity as well as affective versus sensory components were assessed. Results Incision was rated similarly by both groups (BPD: 28.6 +/- 5.5 vs. HC: 33.9 +/- 6.6; mean maximum pain +/- SEM; p > 0.8), without significant difference for 7-s-blade (BPD: 18.1 +/- 3.8 vs. HC: 25.3 +/- 3.6; mean maximum pain +/- SEM; p > 0.17) or between 7-s-blade and incision (BPD: p > 0.12; HC: p > 0.84). However, patients' intensity ratings returned significantly faster to baseline after incision (BPD: 38.9 +/- 12.6 s vs. HC: 74.52 +/- 11.5 s; p < 0.05), and patients evaluated blade and incision without any affective and with different sensory descriptors, indicating an altered evaluation of NSSI-like stimulation with qualitative in addition to quantitative differences-especially for the sharp pain component. Conclusions The reduced perception of suprathreshold nociceptive stimuli is based on a missing affective component and specific loss of the perception of sharpness as part of the sensory component of pain. The results further demonstrate the usefulness of the blade for the perception of sharpness in patients. Significance Patients with Borderline Personality Disorder (BPD) who engage in non-suicidal self-injury (NSSI) report less pain in response to phasic nociceptive stimuli. In comparing an invasive pain stimulus to phasic nociceptive stimuli in BPD patients, the blade as non-invasive surrogate model for sharp mechanical pain in psychiatric patients is used. In contrast to healthy volunteers, BPD patients do not report significant affective ratings and specifically display a reduced sensory component for sharpness.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schloss, Natalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Shabes, Polina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuniss, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Willis, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Treede, Rolf-Detlef UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmahl, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumgaertner, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143243
DOI:	10.1002/ejp.1411
Journal or Publication Title:	Eur. J. Pain
Volume:	23
Number:	8
Page Range:	S. 1448 - 1464
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1532-2149
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSUICIDAL SELF-INJURY; LASER-EVOKED POTENTIALS; HUMAN SURROGATE MODEL; C-FIBER NOCICEPTORS; STRESS REGULATION; SAMPLE-SIZE; POWER; MECHANISMS; INCISION; ANTINOCICEPTION Multiple languages Anesthesiology; Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14324