Universität zu Köln

Brinkkoetter, Paul Thomas, Grundmann, Franziska, Ghassabeh, Panteha Jazayeri, Becker, Ingrid ORCID: 0000-0001-5829-3553, Johnsen, Marc, Suarez, Victor, Schulz, Ralf-Joachim, Streichert, Thomas and Burst, Volker (2019). Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients. Sci Rep, 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age >= 70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive function, motor performance and mood stability was applied on admission and at discharge. Changes of individual test results (Delta) were analyzed and normonatremic patients matched for age, gender, and ADL served as reference group. Most CGA test results improved. The improvement was more pronounced in the hyponatremia group with respect to ADL (Delta ADL: 14.3 +/- 17.1 vs. 9.8 +/- 14.7; p = 0.002) and MMSE (Delta MMSE: 1.8 +/- 3.0 vs. 0.7 +/- 1.9; p = 0.002). Effect sizes were small (i.e., >0.2) in the overall analysis for Delta ADL and Delta MMSE and moderate (i.e., >0.5) for Delta MMSE in the euvolemic subgroup. Beneficial effects on Delta ADL and Delta MMSE were only observed in the subgroup of patients in which [Na+] was raised by >5 mEq/L and multivariable linear regression analysis confirmed [Na+] increase to be an independent predictor of MMSE improvement. Resolution of hyponatremia has a beneficial impact on the geriatric patients' overall functional status, in particular in euvolemic cases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brinkkoetter, Paul Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Grundmann, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghassabeh, Panteha Jazayeri UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ingrid UNSPECIFIED orcid.org/0000-0001-5829-3553 UNSPECIFIED Johnsen, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Suarez, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Ralf-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Burst, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143813
DOI:	10.1038/s41598-019-49054-8
Journal or Publication Title:	Sci Rep
Volume:	9
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK; FRACTURE; OSTEOPOROSIS; PREVALENCE; ADULTS; STATE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14381