Universität zu Köln

Chipollini, Juan ORCID: 0000-0003-2603-0382, Azizi, Mounsif, Lo Vullo, Salvatore, Mariani, Luigi, Zhu, Yao, Ye, Ding W., Ornellas, Antonio Augusto, Watkin, Nick, Ager, Michael, Hakenberg, Oliver, Heidenreich, Axel, Raggi, Daniele ORCID: 0000-0003-4105-9968, Catanzaro, Mario, Ornellas, Paulo, Salvioni, Roberto, Cheriyan, Salim K., Necchi, Andrea and Spiess, Phillippe E. (2020). Identifying an optimal lymph node yield for penile squamous cell carcinoma: prognostic impact of surgical dissection. BJU Int., 125 (1). S. 82 - 89. HOBOKEN: WILEY. ISSN 1464-410X

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Abstract

Objective To evaluate the prognostic impact of lymph node yield (LNY) on survival outcomes for penile squamous cell carcinoma (SCC). Patients and methods In all, 532 patients who underwent inguinal LN dissection (ILND) across tertiary referral centres from Europe, China, Brazil and North America were retrospectively evaluated. From this cohort, 198 patients received pelvic LND (PLND).We identified threshold values for ILND and PLND using receiver operating characteristic curves. We tested prognostic value of LNY for recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) using the Kaplan-Meir method and Cox proportional hazard regression models. Results The median (interquartile [IQR]) age was 59 (49-68) years and the median (IQR) follow-up after ILND was 28 (12-68.2) months. Overall, 85% of the patients had bilateral dissections. The median (IQR) number of inguinal LNs removed was 15 (10-22). Of those receiving PLND, The median (IQR) number of LNs was 13 (8-19). A LNY of >= 15 was used for dichotomisation of ILND patients, and a LNY of >= 9 was used in the PLND cohort. Patients with a LNY >= 15 had significantly better 5-year OS vs patients with a LNY <15 (70.1% vs 58.7%). On multivariable analyses, a LNY >= 15 was a predictor of OS (hazard ratio [HR] 0.68, P = 0.029). For cN0 patients, a LNY >= 15 was an independent predictor of RFS (HR 0.52, P = 0.043) and OS (HR 0.53, P = 0.021). In the PLND cohort, a LNY >= 9 was a predictor of RFS (HR 0.53, P = 0.032). Conclusions Using one of the largest LND datasets to date, we found LNY to be a significant predictor of outcomes after lymphatic staging for penile SCC. Prospective validation is warranted.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chipollini, Juan UNSPECIFIED orcid.org/0000-0003-2603-0382 UNSPECIFIED Azizi, Mounsif UNSPECIFIED UNSPECIFIED UNSPECIFIED Lo Vullo, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Mariani, Luigi UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhu, Yao UNSPECIFIED UNSPECIFIED UNSPECIFIED Ye, Ding W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ornellas, Antonio Augusto UNSPECIFIED UNSPECIFIED UNSPECIFIED Watkin, Nick UNSPECIFIED UNSPECIFIED UNSPECIFIED Ager, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hakenberg, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Raggi, Daniele UNSPECIFIED orcid.org/0000-0003-4105-9968 UNSPECIFIED Catanzaro, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Ornellas, Paulo UNSPECIFIED UNSPECIFIED UNSPECIFIED Salvioni, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheriyan, Salim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Necchi, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Spiess, Phillippe E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143959
DOI:	10.1111/bju.14883
Journal or Publication Title:	BJU Int.
Volume:	125
Number:	1
Page Range:	S. 82 - 89
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1464-410X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; SURVIVAL; LYMPHADENECTOMY; MANAGEMENT Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14395