Universität zu Köln

Sukiban, Jeyathevy, Voges, Nicole, Dembek, Till A., Pauli, Robin, Visser-Vandewalle, Veerle, Denker, Michael, Weber, Immo ORCID: 0000-0003-2979-234X, Timmermann, Lars and Gruen, Sonja (2019). Evaluation of Spike Sorting Algorithms: Application to Human Subthalamic Nucleus Recordings and Simulations. Neuroscience, 414. S. 168 - 186. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7544

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Abstract

An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single-unit activity from the multi-unit signal. To identify single units, potential spikes are separated with respect to their potential neuronal origins ('spike sorting'). However, different sorting algorithms yield inconsistent unit assignments, which seriously influences subsequent spike train analyses. We aim to identify the best sorting algorithm for subthalamic nucleus recordings of patients with Parkinson's disease (experimental data ED). Therefore, we apply various prevalent algorithms offered by the 'Plexon Offline Sorter' and evaluate the sorting results. Since this evaluation leaves us unsure about the best algorithm, we apply all methods again to artificial data (AD) with known ground truth. AD consists of pairs of single units with different shape similarity embedded in the background noise of the ED. The sorting evaluation depicts a significant influence of the respective methods on the single unit assignments. We find a high variability in the sortings obtained by different algorithms that increases with single units shape similarity. We also find significant differences in the resulting firing characteristics. We conclude that Valley-Seeking algorithms produce the most accurate result if the exclusion of artifacts as unsorted events is important. If the latter is less important ('clean' data) the K-Means algorithm is a better option. Our results strongly argue for the need of standardized validation procedures based on ground truth data. The recipe suggested here is simple enough to become a standard procedure. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of IBRO.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sukiban, Jeyathevy UNSPECIFIED UNSPECIFIED UNSPECIFIED Voges, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauli, Robin UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Denker, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Immo UNSPECIFIED orcid.org/0000-0003-2979-234X UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruen, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144039
DOI:	10.1016/j.neuroscience.2019.07.005
Journal or Publication Title:	Neuroscience
Volume:	414
Page Range:	S. 168 - 186
Date:	2019
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7544
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCAL-FIELD POTENTIALS; PARKINSONS-DISEASE; NEURONAL DISCHARGE; WAVE-FORMS; CLASSIFICATION; FUTURE; MICRORECORDINGS; IDENTIFICATION; ORGANIZATION; STIMULATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14403