Universität zu Köln

Alcala, N., Leblay, N., Gabriel, A. A. G., Mangiante, L., Hervas, D., Giffon, T., Sertier, A. S., Ferrari, A., Derks, J., Ghantous, A., Delhomme, T. M., Chabrier, A., Cuenin, C., Abedi-Ardekani, B., Boland, A., Olaso, R., Meyer, V, Altmuller, J., Le Calvez-Kelm, F., Durand, G., Voegele, C., Boyault, S., Moonen, L., Lemaitre, N., Lorimier, P., Toffart, A. C., Soltermann, A., Clement, J. H., Saenger, J., Field, J. K., Brevet, M., Blanc-Fournier, C., Galateau-Salle, F., Le Stang, N., Russell, P. A., Wright, G., Sozzi, G., Pastorino, U., Lacomme, S., Vignaud, J. M., Hofman, V, Hofman, P., Brustugun, O. T., Lund-Iversen, M., de Montpreville, V. Thomas, Muscarella, L. A., Graziano, P., Popper, H., Stojsic, J., Deleuze, J. F., Herceg, Z., Viari, A., Nuernberg, P., Pelosi, G., Dingemans, A. M. C., Milione, M., Roz, L., Brcic, L., Volante, M., Papotti, M. G., Caux, C., Sandoval, J., Hernandez-Vargas, H., Brambilla, E., Speel, E. J. M., Girard, N., Lantuejoul, S., McKay, J. D., Foll, M. and Fernandez-Cuesta, L. (2019). Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low-and high-grade lung neuroendocrine neoplasms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Alcala, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leblay, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gabriel, A. A. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mangiante, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hervas, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giffon, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sertier, A. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrari, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Derks, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghantous, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delhomme, T. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chabrier, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cuenin, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abedi-Ardekani, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boland, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Olaso, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Altmuller, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Calvez-Kelm, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Durand, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Voegele, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boyault, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moonen, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemaitre, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lorimier, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toffart, A. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Soltermann, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clement, J. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saenger, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Field, J. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brevet, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blanc-Fournier, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galateau-Salle, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Stang, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Russell, P. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wright, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sozzi, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pastorino, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lacomme, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vignaud, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofman, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofman, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brustugun, O. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lund-Iversen, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Montpreville, V. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Muscarella, L. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graziano, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popper, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stojsic, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deleuze, J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herceg, Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED Viari, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelosi, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dingemans, A. M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Milione, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roz, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brcic, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Volante, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papotti, M. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caux, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandoval, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hernandez-Vargas, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Speel, E. J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Girard, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lantuejoul, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED McKay, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foll, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fernandez-Cuesta, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144098
DOI:	10.1038/s41467-019-11276-9
Journal or Publication Title:	Nat. Commun.
Volume:	10
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL LUNG-CANCER; NEUROENDOCRINE TUMORS; DENDRITIC CELLS; EXPRESSION; CLASSIFICATION; MUTATIONS; DISCOVERY; PATHWAY; HEALTH; IDENTIFICATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14409