Universität zu Köln

Isaacs, Bethany. R., Trutti, Anne. C., Pelzer, Esther, Tittgemeyer, Marc, Temel, Yasin, Forstmann, Birte. U. and Keuken, Max. C. (2019). Cortico-basal white matter alterations occurring in Parkinson's disease. PLoS One, 14 (8). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with both age and disease. The present study utilizes Parkinson's disease and age-specific anatomical atlases of the subthalamic nucleus for diffusion tractography, assessing tracts that run between the subthalamic nucleus and a-priori defined cortical areas known to be affected by Parkinson's disease. The results show that the strength of white matter fiber tracts appear to remain structurally unaffected by disease. Contrary to that, Fractional Anisotropy values were shown to decrease in Parkinson's disease patients for connections between the subthalamic nucleus and the pars opercularis of the inferior frontal gyrus, anterior cingulate cortex, the dorsolateral prefrontal cortex and the pre-supplementary motor, collectively involved in preparatory motor control, decision making and task monitoring. While the biological underpinnings of fractional anisotropy alterations remain elusive, they may nonetheless be used as an index of Parkinson's disease. Moreover, we find that failing to account for structural changes occurring in the subthalamic nucleus with age and disease reduce the accuracy and influence the results of tractography, highlighting the importance of using appropriate atlases for tractography.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Isaacs, Bethany. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trutti, Anne. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelzer, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Temel, Yasin UNSPECIFIED UNSPECIFIED UNSPECIFIED Forstmann, Birte. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keuken, Max. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144119
DOI:	10.1371/journal.pone.0214343
Journal or Publication Title:	PLoS One
Volume:	14
Number:	8
Date:	2019
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; HUMAN SUBTHALAMIC NUCLEUS; ANTERIOR CINGULATE CORTEX; FUNCTIONAL CONNECTIVITY; INDIVIDUAL-DIFFERENCES; FREE-WATER; SUBSTANTIA-NIGRA; FRONTAL-CORTEX; RESTING-STATE; STRUCTURAL CONNECTIVITY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14411