Sobanski, Vincent ORCID: 0000-0003-3083-2441, Giovannelli, Jonathan, Allanore, Yannick, Riemekasten, Gabriela, Airo, Paolo, Vettori, Serena, Cozzi, Franco, Distler, Oliver ORCID: 0000-0002-0546-8310, Matucci-Cerinic, Marco, Denton, Christopher, Launay, David, Hachulla, Eric, Cerinic, Marco Matucci, Guiducci, Serena ORCID: 0000-0003-2722-6475, Walker, Ulrich, Kyburz, Diego, Lapadula, Giovanni ORCID: 0000-0002-8427-6092, Iannone, Florenzo ORCID: 0000-0003-0474-5344, Distler, Oliver ORCID: 0000-0002-0546-8310, Maurer, Britta, Jordan, Suzana, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, Andre, Allanore, Yannick, Vlachoyiannopoulos, Panayiotis, Montecucco, Carlo, Caporali, Roberto, Stork, Jiri ORCID: 0000-0002-8505-3560, Inanc, Murat, Carreira, Patricia E., Novak, Srdan ORCID: 0000-0001-8870-4704, Czirjak, Laszlo, Varju, Cecilia ORCID: 0000-0002-6849-9114, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Airo, Paolo, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, Francesco, Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Nuova, Arcispedale Santa Maria, Salvador, Maria Joao, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Marasini, Bianca, Tikly, Mohammed, Ananieva, Lidia P., Denisov, Lev N., Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriella, Szamosi, Szilvia, Zea Mendoza, Antonio, de la Puente, Carlos, Sifuentes Giraldo, Walter Alberto ORCID: 0000-0003-2548-3988, Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Hachulla, Eric, Launay, David, Valesini, Guido ORCID: 0000-0002-7757-8092, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M., Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Mihai, Carina, Milicescu, Mihaela, Sunderkoetter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Distler, Joerg H. W., Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, von Muehlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir ORCID: 0000-0003-4940-0577, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas ORCID: 0000-0003-2802-4971, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo ORCID: 0000-0002-7417-8093, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario ORCID: 0000-0002-7301-8362, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E., Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Eduardo, Andrade Luis C., Fathi, Nihal, Hassanien, Manal, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Kahl, Sarah, Hsu, Vivien M., Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Pasquali, Jean Louis, Martin, Thierry, Gorse, Audrey, Guffroy, Aurelien and Poindron, Vincent
(2019).
Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis.
Arthritis Rheumatol., 71 (9).
S. 1553 - 1571.
HOBOKEN:
WILEY.
ISSN 2326-5205
Full text not available from this repository.
Abstract
Objective Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. Methods A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. Results Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. Conclusion Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis.
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Journal Article
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Sobanski, Vincent | UNSPECIFIED | orcid.org/0000-0003-3083-2441 | UNSPECIFIED | Giovannelli, Jonathan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allanore, Yannick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riemekasten, Gabriela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Airo, Paolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vettori, Serena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cozzi, Franco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Distler, Oliver | UNSPECIFIED | orcid.org/0000-0002-0546-8310 | UNSPECIFIED | Matucci-Cerinic, Marco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Denton, Christopher | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Launay, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hachulla, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cerinic, Marco Matucci | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guiducci, Serena | UNSPECIFIED | orcid.org/0000-0003-2722-6475 | UNSPECIFIED | Walker, Ulrich | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kyburz, Diego | 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UNSPECIFIED | Martin, Thierry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gorse, Audrey | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guffroy, Aurelien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Poindron, Vincent | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-144437 |
DOI: |
10.1002/art.40906 |
Journal or Publication Title: |
Arthritis Rheumatol. |
Volume: |
71 |
Number: |
9 |
Page Range: |
S. 1553 - 1571 |
Date: |
2019 |
Publisher: |
WILEY |
Place of Publication: |
HOBOKEN |
ISSN: |
2326-5205 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
DISEASE; CLASSIFICATION; SUBSETS; MANIFESTATIONS; CRITERIA; PROFILE | Multiple languages | Rheumatology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/14443 |
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