Knudsen, K., Krack, P., Tonder, L., Houeto, J. -L., Rau, J., Schade-Brittinger, C., Hartmann, A., Haelbig, Thomas D., Paschen, Stephen, Barbe, Michael T., Kuehn, Andrea, Fraix, Valerie, Brefel-Courbon, Christine, Vesper, Jan, Maltete, David, Sixel-Doering, Friederike, Weiss, Daniel, Witjas, Tatiana, Thobois, Stephane, Agid, Yves, Schnitzler, A., Schuepbach, W. M. M., Timmermann, L., Damier, Philippe, Vidailhet, M., Deuschl, G., Czernecki, Virginie, Hesekamp, Helke, Meier, Nildaus, Negovanska, Velina, Welter, Marie-Laure, Corvol, Jean-Christophe ORCID: 0000-0001-7325-0199, Pineau, Fanny, Cornu, Philippe, Navarro, Soledad, Paschen, Laura, Paschen, Stephen, Volkmann, Jens, Moeller, Bettina, Nebel, Adelheid, Witt, Karsten, Raethjen, Jan, Falk, Daniels, Mehdorn, Maktnilian, Meister, Ingo G., Kuhn, Jens, Dafsari, Haidar S., Fink, Gereon, Donner, Kerstin, Kessler, Josef, Maarouf, Mohammad, Kupsch, Andeas, Schneider, Gerd -H., Gruber, Doreen, Mueller, Bianca, Faust, Katharina, Chabardes, Stephan, Kistler, Andrea, Pollak, Pierre, Ory-Magne, Fabienne, Rascol, Oliver, Arbus, Christophe, Chaynes, P. Patrick, Danet, Lola, Derrey, Stephane, Lefaucheur, Romain, Benatru, Isabelle, Bataille, Benoit, Colin, Olivier, Wojtecki, Lars, Groiss, Stefan J., Elben, Saskia, Hartmann, Christian, Suedmeyer, Martin, Pinsker, Marcus O., Amtage, Florian, Gharabaghi, Alireza, Waechter, Tobias, Kruger, Rejko, Derkinderen, Pascal, Ledily, Severine, Raoul, Sylvia, Sauvaget, Anne, Elena-Klinik, Paracelsus, Trenkwalder, Claudia, Richter-Dreske, Wenke, Regis, Jean-Marie, Eusebio, Alexandro, Philippe, Jean, Polo, Gustavo, Pinto, Serge, Mertens, Patrick, Levin, Johannes ORCID: 0000-0001-5092-4306, Oertel, Wolfgang H., Dornier, Stephanie, Pene, Fredy, Hourton, Delphine, Bissery, Anne, Bouton, Didier, Quintin, Mathieu, Hoffart-Jourdain, Cecile, Brocvielle, Helene, Partowinia-Peters, Mahnaz, Schickor, Mandy, Balthasar, Kerstin, Stein, Meryem, Harnisch, Susanne, Reuss, Alexander, Aminossadati, Behnaz, Nasemann, Christian and Stoker, Valerie (2019). Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial. Parkinsonism Relat. Disord., 65. S. 217 - 224. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Background: Programming algorithms have never been tested for outcome. The EARLYSTIM study showed superior outcomes of deep brain stimulation of the subthalamic nucleus (STN-DBS) over best medical treatment in early Parkinson's disease (PD). Patients were programmed according to common guidelines but customized for each patient. Methods: Stimulation parameters were systematically documented at 1, 5, 12, and 24 month in the cohort of 114 patients who had bilateral STN-DBS at 24 month. We investigated the influence of atypical programming, changes of stimulated electrode contacts and stimulation energy delivered. Outcomes were the Unified Parkinson's Disease Rating Scale (UPDRS) motor and ADL-subscores, health-related quality of life (PDQ-39) summary index and mobility- and ADL-subscores. Results: At 1/5/12/24 months follow up, mean amplitude (1.8/2.5/2.6/2.8 V), impedance (1107/1286/1229/1189 Omega) and TEED (33.7/69.0/84.4/93.0 V2*mu s*Hz/Omega) mainly increased in the first 5 months, while mean pulse width (60.0/62.5/65.1/65.8 mu s), frequency (130/137.7/139.1/142.7 Hz) remained relatively stable. Typical programming (single monopolar electrode contact) was used in 80.7% of electrodes. Double monopolar (11/114) and bipolar (2/114) stimulation was only rarely required. There was no significant difference in clinical outcomes between the patient groups requiring contact changes (n = 32/28.1%) nor between (n = 83/72.8%) versus non-typical programming. Energy used for STN-DBS was higher for the dominant side of PD. Conclusion: In the first 5 months an increase in amplitude is required to compensate for various factors. Monopolar stimulation is sufficient in 80% of patients at 24 months. Homogeneous stimulation strategies can account for the favorable outcomes reported in the Earlystim study.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Knudsen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krack, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tonder, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houeto, J. -L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rau, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schade-Brittinger, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haelbig, Thomas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fraix, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brefel-Courbon, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesper, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maltete, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sixel-Doering, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witjas, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thobois, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agid, YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuepbach, W. M. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidailhet, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czernecki, VirginieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hesekamp, HelkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, NildausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Negovanska, VelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Welter, Marie-LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corvol, Jean-ChristopheUNSPECIFIEDorcid.org/0000-0001-7325-0199UNSPECIFIED
Pineau, FannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornu, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navarro, SoledadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nebel, AdelheidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raethjen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falk, DanielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehdorn, MaktnilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meister, Ingo G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhn, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, GereonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donner, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maarouf, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupsch, AndeasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, Gerd -H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruber, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, BiancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faust, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chabardes, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kistler, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pollak, PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ory-Magne, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rascol, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arbus, ChristopheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaynes, P. PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danet, LolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derrey, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lefaucheur, RomainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benatru, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bataille, BenoitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colin, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wojtecki, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groiss, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elben, SaskiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suedmeyer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinsker, Marcus O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amtage, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gharabaghi, AlirezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waechter, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruger, RejkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derkinderen, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ledily, SeverineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raoul, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauvaget, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elena-Klinik, ParacelsusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter-Dreske, WenkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regis, Jean-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eusebio, AlexandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Philippe, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polo, GustavoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, SergeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mertens, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levin, JohannesUNSPECIFIEDorcid.org/0000-0001-5092-4306UNSPECIFIED
Oertel, Wolfgang H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dornier, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pene, FredyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hourton, DelphineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bissery, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouton, DidierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quintin, MathieuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffart-Jourdain, CecileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brocvielle, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Partowinia-Peters, MahnazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schickor, MandyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balthasar, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, MeryemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harnisch, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuss, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aminossadati, BehnazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nasemann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoker, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-145008
DOI: 10.1016/j.parkreldis.2019.05.023
Journal or Publication Title: Parkinsonism Relat. Disord.
Volume: 65
Page Range: S. 217 - 224
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1873-5126
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NUCLEUS; LEVODOPA; NEUROSTIMULATION; SENSITIZATION; GAITMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14500

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