Universität zu Köln

Klug, Alexander ORCID: 0000-0002-5239-0405, Park, Su-Chan and Krug, Joachim (2019). Recombination and mutational robustness in neutral fitness landscapes. PLoS Comput. Biol., 15 (8). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7358

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Abstract

Mutational robustness quantifies the effect of random mutations on fitness. When mutational robustness is high, most mutations do not change fitness or have only a minor effect on it. From the point of view of fitness landscapes, robust genotypes form neutral networks of almost equal fitness. Using deterministic population models it has been shown that selection favors genotypes inside such networks, which results in increased mutational robustness. Here we demonstrate that this effect is massively enhanced by recombination. Our results are based on a detailed analysis of mesa-shaped fitness landscapes, where we derive precise expressions for the dependence of the robustness on the landscape parameters for recombining and non-recombining populations. In addition, we carry out numerical simulations on different types of random holey landscapes as well as on an empirical fitness landscape. We show that the mutational robustness of a genotype generally correlates with its recombination weight, a new measure that quantifies the likelihood for the genotype to arise from recombination. We argue that the favorable effect of recombination on mutational robustness is a highly universal feature that may have played an important role in the emergence and maintenance of mechanisms of genetic exchange.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klug, Alexander UNSPECIFIED orcid.org/0000-0002-5239-0405 UNSPECIFIED Park, Su-Chan UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145038
DOI:	10.1371/journal.pcbi.1006884
Journal or Publication Title:	PLoS Comput. Biol.
Volume:	15
Number:	8
Date:	2019
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7358
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOM INDUCED SUBGRAPHS; ADAPTIVE EVOLUTION; SEX; EPISTASIS; SELECTION; PERSPECTIVE; ADVANTAGE; ROLES; RATES Multiple languages Biochemical Research Methods; Mathematical & Computational Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14503