Universität zu Köln

Flueckiger, Rahel, Michel, Chantal ORCID: 0000-0003-1165-6681, Grant, Phillip, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Vogeley, Kai, Hubl, Daniela, Schimmelmann, Benno G., Klosterkoetter, Joachim, Schmidt, Stefanie J. and Schultze-Lutter, Frauke (2019). The interrelationship between schizotypy, clinical high risk for psychosis and related symptoms: Cognitive disturbances matter. Schizophr. Res., 210. S. 188 - 197. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Schizotypy and clinical high risk (CHR) criteria can identify individuals who are at increased risk for developing psychosis in community and patient samples. However, both approaches have rarely been combined, and very little is known about their associations. Therefore, we examined the factorial structure of CHR and related symptoms and schizotypy features as well as their interrelationship for the first time in a comprehensive approach. In a sample of 277 patients (22 +/- 6 years) from two early detection services, structural equation modeling including confirmatory factor analysis was performed to test a theory-driven model using four Wisconsin Schizotypy Scales, 14 predictive basic symptoms (BS) of the Schizophrenia Proneness Instrument, and positive, negative, and disorganized symptoms from the Structured Interview for Psychosis-Risk Syndromes. The data fitted well to the six hypothesized latent factors consisting of negative schizotypy, positive schizotypy including perceptual BS, negative symptoms, positive symptoms, disorganized symptoms and cognitive disturbances. As postulated, schizotypy features were significantly associated with positive, negative and disorganized symptoms through cognitive disturbances. Additionally, positive and negative schizotypy also had a direct association with the respective symptom-domain. While the identified factorial structure corresponds well to dimensional models of schizotypy and psychoses, our model extends earlier models by indicating that schizotypy features are associated with positive, negative and disorganized symptoms directly or indirectly via subjective cognitive disturbances. This calls for more attention to subjective cognitive deficits in combination with heightened schizotypy in the early detection and intervention of psychoses - or even of an Attenuated Psychosis Syndrome. (C) 2019 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Flueckiger, Rahel UNSPECIFIED UNSPECIFIED UNSPECIFIED Michel, Chantal UNSPECIFIED orcid.org/0000-0003-1165-6681 UNSPECIFIED Grant, Phillip UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Vogeley, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Hubl, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Schimmelmann, Benno G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Stefanie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145823
DOI:	10.1016/j.schres.2018.12.039
Journal or Publication Title:	Schizophr. Res.
Volume:	210
Page Range:	S. 188 - 197
Date:	2019
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH-RISK; BASIC SYMPTOMS; PERCEPTUAL ABERRATION; PRONENESS SCALES; PHYSICAL ANHEDONIA; PRODROMAL SYMPTOMS; EPISODE PSYCHOSIS; SOCIAL ANHEDONIA; SCHIZOPHRENIA; PREDICTION Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14582