Universität zu Köln

Hansen, Nienke L., Barrett, Tristan, Lloyd, Thomas ORCID: 0000-0002-2796-709X, Warren, Anne, Samel, Christina, Bratt, Ola and Kastner, Christof (2020). Optimising the number of cores for magnetic resonance imaging-guided targeted and systematic transperineal prostate biopsy. BJU Int., 125 (2). S. 260 - 270. HOBOKEN: WILEY. ISSN 1464-410X

Full text not available from this repository.

Abstract

Objectives To assess cancer detection rates of different target-dependent transperineal magnetic resonance (MR)/ultrasonography (US) fusion-guided biopsy templates with reduced number of systematic cores. Patients and Methods Single-centre outcome of transperineal MR/US fusion-guided biopsies of 487 men with a single target MR imaging (MRI) lesion, prospectively collected between 2012 and 2016. All men underwent transperineal targeted biopsy (TB) with two cores, followed by 18-24 systematic sector biopsies (SB) using the Ginsburg protocol. Gleason score >= 7 prostate cancer detection rates for two-core TB, four-core extended TB (eTB), 10- to 20-core saturation TB (sTB) including cores from sectors adjacent to the target, and 14 core ipsilateral TB (iTB) were compared to combined TB+SB. Results Cancer was detected in 345 men and Gleason score 7-10 cancer in 211 men. TB alone detected 67%, eTB 76%, sTB 91% and iTB 91% of these Gleason score 7-10 cancers. In the subgroup of 33 men (7% of cohort) with an anterior >0.5 mL highly suspicious MRI lesion and a prostate volume <= 45 mL, four-core eTB detected 31 of 32 cancers (97%) and all 26 Gleason score 7-10 cancers. Conclusion sTB detected Gleason score 7-10 cancer in 25% more of the men than a two-core TB approach, and in almost as many men (91%) as the 20-26-core combined TB+SB, while needing only 10-20 cores. A four-core extended TB may suffice for large, highly suspicious anterior lesions in small or slightly enlarged prostates.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hansen, Nienke L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrett, Tristan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lloyd, Thomas UNSPECIFIED orcid.org/0000-0002-2796-709X UNSPECIFIED Warren, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Samel, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bratt, Ola UNSPECIFIED UNSPECIFIED UNSPECIFIED Kastner, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145916
DOI:	10.1111/bju.14865
Journal or Publication Title:	BJU Int.
Volume:	125
Number:	2
Page Range:	S. 260 - 270
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1464-410X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISUP CONSENSUS CONFERENCE; INTERNATIONAL-SOCIETY; FUSION BIOPSY; MRI; CANCER; DIAGNOSIS; VOLUME Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14591