Universität zu Köln

Gorges, Martin, Mueller, Hans-Peter, Liepelt-Scarfone, Inga, Storch, Alexander, Dodel, Richard, Hilker-Roggendorf, Ruediger, Berg, Daniela, Kunz, Martin S., Kalbe, Eike, Baudrexel, Simon, Kassubek, Jan ORCID: 0000-0002-7106-9270, Baudrexel, S., Dodel, R., Berg, D., Hilker-Roggendorf, R., Kalbe, E., Kassubek, J., Mollenhauer, B., Schulz, J., Spottke, A., Storch, A. and Wittchen, H-U (2019). Structural brain signature of cognitive decline in Parkinson's disease: DTI-based evidence from the LANDSCAPE study. Ther. Adv. Neurol. Disord., 12. LONDON: SAGE PUBLICATIONS LTD. ISSN 1756-2864

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Abstract

Background: The nonmotor symptom spectrum of Parkinson's disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia. Methods: Diffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures. Results: Structural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) total score. Conclusions: The findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gorges, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker-Roggendorf, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunz, Martin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Eike UNSPECIFIED UNSPECIFIED UNSPECIFIED Baudrexel, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Baudrexel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker-Roggendorf, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, H-U UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-148717
DOI:	10.1177/1756286419843447
Journal or Publication Title:	Ther. Adv. Neurol. Disord.
Volume:	12
Date:	2019
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1756-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIAGNOSTIC-CRITERIA; IMPAIRMENT; DIFFUSION; MULTICENTER; DEMENTIA; CONNECTOME; INTEGRITY; NETWORKS; MRI Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14871