Universität zu Köln

Roediger, Jan, Artusi, Carlo Alberto ORCID: 0000-0001-8579-3772, Romagnolo, Alberto ORCID: 0000-0002-1312-1843, Boyne, Pierce, Zibetti, Maurizio ORCID: 0000-0002-2939-343X, Lopiano, Leonardo, Espay, Alberto J. ORCID: 0000-0002-3389-136X, Fasano, Alfonso ORCID: 0000-0001-5346-0180 and Merola, Aristide ORCID: 0000-0002-5587-726X (2019). Effect of subthalamic deep brain stimulation on posture in Parkinson's disease: A blind computerized analysis. Parkinsonism Relat. Disord., 62. S. 122 - 128. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: We sought to assess the effect of subthalamic deep brain stimulation (STN DBS) on Parkinson's disease (PD)-associated postural abnormalities. Methods: A computerized analysis of posture was used to quantify the thoracolumbar, thoracic, and cervical occipital ventral angles, as well as the thoracolumbar and cervical-occipital lateral angles from the video-repository of three specialized movement disorder centers (n = 158 patients). Data was extracted from frames from video-recordings in the pre-surgical medication-ON (dopaminergic therapy) and post-surgical stimulation-ON/medication-ON states (STN DBS plus dopaminergic therapy). The sum of the five postural angles (global postural angle) was used to compare pre-vs. post-surgical trunk posture alterations. A multivariate analysis was used to examine the association between changes in the postural angles and demographic or clinical variables. Results: There was a 6.7% amelioration in the global postural angle between the pre- and post-surgical assessments (p = 0.031). Motor response to and pre-surgical dosage of levodopa, male gender, and shorter PD duration were identified as predictors for posture improvement after STN DBS. Cases meeting criteria for lower (n = 2) or upper (n = 1) camptocormia respectively improved by 48.1% in the ventral thoracolumbar angle (from 36.4 +/- 0.0 degrees to 18.9 +/- 4.2 degrees) and 13.8% in the ventral thoracic angle (from 49.1 degrees to 42.3 degrees). Cases meeting criteria for Pisa syndrome (n = 2) improved by 67.5% in the lateral thoracolumbar angle (from 16.9 +/- 2.0 degrees to 5.5 +/- 4.7 degrees). Conclusions: STN DBS has a relatively small but significant effect on PD-associated postural abnormalities, potentially enhancing the effect of dopaminergic medications alone.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roediger, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Artusi, Carlo Alberto UNSPECIFIED orcid.org/0000-0001-8579-3772 UNSPECIFIED Romagnolo, Alberto UNSPECIFIED orcid.org/0000-0002-1312-1843 UNSPECIFIED Boyne, Pierce UNSPECIFIED UNSPECIFIED UNSPECIFIED Zibetti, Maurizio UNSPECIFIED orcid.org/0000-0002-2939-343X UNSPECIFIED Lopiano, Leonardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Espay, Alberto J. UNSPECIFIED orcid.org/0000-0002-3389-136X UNSPECIFIED Fasano, Alfonso UNSPECIFIED orcid.org/0000-0001-5346-0180 UNSPECIFIED Merola, Aristide UNSPECIFIED orcid.org/0000-0002-5587-726X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-148771
DOI:	10.1016/j.parkreldis.2019.01.003
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	62
Page Range:	S. 122 - 128
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PISA SYNDROME; NUCLEUS STIMULATION; CAMPTOCORMIA; LEVODOPA; ABNORMALITY; DEFORMITIES Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14877