Universität zu Köln

Doss, Michael Xavier and Sachinidis, Agapios (2019). Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications. Cells, 8 (5). BASEL: MDPI. ISSN 2073-4409

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Abstract

Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement therapy approach have proven to be very powerful and instrumental in biomedical research and personalized regenerative medicine as evidenced in the past decade by unraveling novel pathological mechanisms of a multitude of monogenic diseases at the cellular level and the ongoing and emerging clinical trials with iPSC-derived cell products. iPSC-based disease modelling has sparked widespread enthusiasm and has presented an unprecedented opportunity in high throughput drug discovery platforms and safety pharmacology in association with three-dimensional multicellular organoids such as personalized organs-on-chips, gene/base editing, artificial intelligence and high throughput omics methodologies. This critical review summarizes the progress made in the past decade with the advent of iPSC discovery in biomedical applications and regenerative medicine with case examples and the current major challenges that need to be addressed to unleash the full potential of iPSCs in clinical settings and pharmacology for more effective and safer regenerative therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doss, Michael Xavier UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachinidis, Agapios UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-148983
DOI:	10.3390/cells8050403
Journal or Publication Title:	Cells
Volume:	8
Number:	5
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLURIPOTENT STEM-CELLS; EPIGENETIC MEMORY; ENDOTHELIAL-CELLS; GENERATION; CANCER; MOUSE; CARDIOMYOCYTES; EFFICIENT; TOOL; DIFFERENTIATION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14898