Universität zu Köln

Rhiem, Kerstin, Buecker-Nott, Hans-Joachim, Hellmich, Martin, Fischer, Holger, Ataseven, Beyhan, Dittmer-Grabowski, Christine, Latos, Kunibert, Pelzer, Volker, Seifert, Manuela, Schmidt, Andrea, Rezek, Daniela, Groh, Ulrich, Meinerz, Wolfgang, Crommelinck, Dirk, Hahnen, Eric, Wesselmann, Simone and Schmutzler, Rita Katharina (2019). Benchmarking of a checklist for the identification of familial risk for breast and ovarian cancers in a prospective cohort. Breast J., 25 (3). S. 455 - 461. HOBOKEN: WILEY. ISSN 1524-4741

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Abstract

The detection of deleterious germline mutations in BRCA1 and BRCA2 considerably influences the clinical management of healthy and diseased carriers. Therefore, the identification of persons at risk who could uptake genetic counseling and testing is pivotal. We developed a checklist with validated criteria to improve the identification, and prospectively evaluate the incidence, of familial cancer history in 5091 breast cancer patients. The rate of 30.4% of patients at high genetic risk underpins the demand for care in risk identification and counseling. The easy-to-use instrument promotes the implementation and dissemination of risk counseling by physicians.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Buecker-Nott, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Ataseven, Beyhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dittmer-Grabowski, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Latos, Kunibert UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelzer, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Manuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Rezek, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Groh, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinerz, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Crommelinck, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahnen, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Wesselmann, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149211
DOI:	10.1111/tbj.13257
Journal or Publication Title:	Breast J.
Volume:	25
Number:	3
Page Range:	S. 455 - 461
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1524-4741
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA1; WOMEN Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14921