Universität zu Köln

Mokhtar, Amira B., Ahmed, Shahira A., Eltamany, Enas E. and Karanis, Panagiotis (2019). Anti-Blastocystis Activity In Vitro of Egyptian Herbal Extracts (Family: Asteraceae) with Emphasis on Artemisia judaica. Int. J. Environ. Res. Public Health, 16 (9). BASEL: MDPI. ISSN 1660-4601

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Abstract

Achillea fragrantissima (Forssk.) Sch. Bip. (known as Qaysoom), Echinops spinosus L. (known as Shoak Elgamal) and Artemisia judaica L. (known Shih Baladi) are members of the Asteraceae family known for their traditional medical use in Egypt. The ethanol extracts of these plants were evaluated for their efficacy against a protozoan parasite (Blastocystis). Two different molecular subtypes of Blastocystis were used (ST1 and ST3). Significant growth inhibition of Blastocystis was observed when exposed to both A. judaica (99.3%) and A. fragrantissima (95.6%) with minimal inhibitory concentration (MIC90) at 2000 mu g/mL. Under the effect of the extracts, changes in Blastocystis morphology were noted, with the complete destruction of Blastocystis forms after 72 h with the dose of 4000 mu g/mL. Different subtypes displayed different responses to the herbal extracts tested. ST1 exhibited significantly different responses to the herbal extracts compared to ST3. A. judaica was selected as the herb of choice considering all of its variables and because of its effective action against Blastocystis. It was then exposed to further fractionation and observation of its effect on ST1 and ST3. Solvent portioned fractions (dichloromethane (DCM), ethyl acetate (EtOAc) and n-hexane) in A. judaica were found to be the potent active fractions against both of the Blastocystis subtypes used.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mokhtar, Amira B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahmed, Shahira A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eltamany, Enas E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karanis, Panagiotis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149270
DOI:	10.3390/ijerph16091555
Journal or Publication Title:	Int. J. Environ. Res. Public Health
Volume:	16
Number:	9
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-4601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACHILLEA-FRAGRANTISSIMA; SESQUITERPENE LACTONES; MEDICINAL-PLANTS; ESSENTIAL OIL; SPP.; L.; CLASSIFICATION; FLAVONOIDS; DIVERSITY; CHILDREN Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14927