Universität zu Köln

Findeklee, Sebastian ORCID: 0000-0002-2921-0664, Sklavounos, Panagiotis, Stotz, Lisa, Sima, Romina M., Iordache, Iulian, Spuentrup, Carolin, Kasoha, Mariz, Thangarajah, Fabinshy, Solomayer, Erich-Franz and Radosa, Julia C. (2019). Influence of androgen levels on conception probability in patients undergoing fertility treatment: a retrospective cohort study. Arch. Gynecol. Obstet., 299 (5). S. 1481 - 1486. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

PurposePrimary and secondary sterility have become an issue of increasing importance due to demographic and social changes in society. Data regarding the association between female androgen levels and the probability of successful conception after fertility treatment are sparse and contradictive. This study was designed to assess this clinical question.MethodsIn this retrospective single-center cohort study concentrations of androgens androstenedione, dehydroepiandrosteronsulfat (DHEAS) and testosterone (ng/ml) were investigated in the serum of patients presenting for sterility at the department of reproductive medicine of Saarland University hospital Homburg between January 2015 and December 2017. Androgen levels were correlated with reproductive outcomes. Statistical analysis was performed with the aid of SPSS version 24. Significance for conception rates in dependence of androgen concentration was assessed using Kruskal-Wallis test (significance was estimated with p<0.05).ResultsThe laboratory values of a total of 301 patients were examined (64% primary, 36% secondary sterility). Median age at first visit at the fertility department was 32.7years (range 20-47years). 64 pregnancies were observed during the study period (conception rate 21.3%). 23 out of 301 patients (7.6%) suffered from hypoandrogenaemia, 248 (82.4%) had normal androgen levels and 30 (10%) showed hyperandrogenaemia (p=0.25). Regarding patients in whom fertility treatment was successful 3 (4.7%) showed hypoandrogenaemia, 54 (84.4%) were normoandrogenaemic and 7 (10.9%) had hyperandrogenaemia (p=0.40 Kruskal-Wallis test).ConclusionsWe found no association between female androgen levels and sterility and reproductive outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Findeklee, Sebastian UNSPECIFIED orcid.org/0000-0002-2921-0664 UNSPECIFIED Sklavounos, Panagiotis UNSPECIFIED UNSPECIFIED UNSPECIFIED Stotz, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Sima, Romina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Iordache, Iulian UNSPECIFIED UNSPECIFIED UNSPECIFIED Spuentrup, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasoha, Mariz UNSPECIFIED UNSPECIFIED UNSPECIFIED Thangarajah, Fabinshy UNSPECIFIED UNSPECIFIED UNSPECIFIED Solomayer, Erich-Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Radosa, Julia C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149423
DOI:	10.1007/s00404-019-05079-y
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	299
Number:	5
Page Range:	S. 1481 - 1486
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OVARIAN RESPONSE; POOR RESPONDERS; DEHYDROEPIANDROSTERONE; TESTOSTERONE; WOMEN Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14942