Universität zu Köln

Lucas, Carolin Weiss, Kallioniemi, Elisa ORCID: 0000-0001-6706-2837, Neuschmelting, Volker, Nettekoven, Charlotte, Pieczewski, Julia, Jonas, Kristina, Goldbrunner, Roland, Karhu, Jari, Grefkes, Christian ORCID: 0000-0002-1656-720X and Julkunen, Petro (2019). Cortical Inhibition of Face and Jaw Muscle Activity and Discomfort Induced by Repetitive and Paired-Pulse TMS During an Overt Object Naming Task. Brain Topogr., 32 (3). S. 418 - 435. DORDRECHT: SPRINGER. ISSN 1573-6792

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Abstract

Modulatory effects of transcranial magnetic stimulation (TMS) strongly depend on the stimulation parameters. Here, we compared the immediate, task-locked inhibitory effects on speech-related muscles and the tolerability of different TMS protocols during a language production task. Repetitive TMS (rTMS) and paired-pulse TMS (PP) were applied in 13 healthy subjects over the primary motor cortex (M1) during a finger-tapping/tongue-twisting tasks. The lowest subject-specific TMS intensity leading to movement disruptions wasused for TMS over left-sided speech-related areas during picture naming. Here, time-locked PP and rTMS (10/30/50Hz; randomized sequence) were applied. Cortical silent periods (cSPs) were analyzed from electromyography obtained from various face muscles. 30Hz- and 50Hz-rTMS reliably evoked tongue movement disruption (ICC=0.65) at lower rTMS intensities compared to 10Hz-rTMS or PP. CSPs were elicited from the left hemisphere by all TMS protocols, most reliably by PP (p<0.001). Also, cSPs with longest durations were induced by PP. Exploratory analyses of PP suggest that the trials with strongest motor inhibitory effects (presence of cSP) were associated with more articulatory naming errors, hence hinting at the utility of TMS-elicited, facial cSP for mapping of language production areas. Higher-frequency rTMS and PP evoked stronger inhibitory effects as compared to 10Hz-rTMS during a language task, thus enabling a probably more efficient and tolerable routine for language mapping. The spatial distribution of cranial muscle cSPs implies that TMS might affect not only M1, but also distant parts of the language network.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lucas, Carolin Weiss UNSPECIFIED UNSPECIFIED UNSPECIFIED Kallioniemi, Elisa UNSPECIFIED orcid.org/0000-0001-6706-2837 UNSPECIFIED Neuschmelting, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettekoven, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Pieczewski, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Karhu, Jari UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Julkunen, Petro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150022
DOI:	10.1007/s10548-019-00698-9
Journal or Publication Title:	Brain Topogr.
Volume:	32
Number:	3
Page Range:	S. 418 - 435
Date:	2019
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-6792
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; NONINVASIVE BRAIN-STIMULATION; MOTOR EVOKED-POTENTIALS; SILENT PERIOD; NAVIGATED TMS; CORTICOCORTICAL INHIBITION; FACIAL-MUSCLES; CRANIAL NERVES; CORTEX; SAFETY Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15002