Universität zu Köln

Katsigiannis, Sotirios, Krischek, Boris, Barleanu, Stefanie, Grau, Stefan, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Timmer, Marco, Kabbasch, Christoph, Goldbrunner, Roland and Stavrinou, Pantelis (2019). Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma. Radiat. Oncol., 14. LONDON: BMC. ISSN 1748-717X

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Abstract

Background and purposeTo evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol.Materials and methodsPatients with newly diagnosed primary GBM treated with the same therapeutical scheme between 2010 and 2015 in our institution were retrospectively reviewed. The population was trichotomized based on the time interval from surgery till initiation of RT (<28days, 28-33days, >33days). Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis.ResultsOne-hundred-fifty-one patients met the inclusion criteria. Between the three groups no significant difference in PFS (p=0.516) or OS (p=0.902) could be demonstrated. Residual tumor volume (RTV) and midline structures involvement were identified as independent prognostic factors of PFS while age, O-6-Methylguanine Methyltransferase (MGMT) status, Ki67 index, RTV and midline structures involvement represented independent predictors of OS. Patients starting RT after a prolonged delay (>48days) exhibited a significantly shorter OS (p=0.034).ConclusionInitiation of RT within a timeframe of 48days is not associated with worsened survival. A prolonged delay (>48days) may be associated with worse OS. RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Katsigiannis, Sotirios UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Barleanu, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150292
DOI:	10.1186/s13014-019-1272-6
Journal or Publication Title:	Radiat. Oncol.
Volume:	14
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1748-717X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; ADJUVANT TEMOZOLOMIDE; RADIATION-THERAPY; MALIGNANT GLIOMA; DELAY; TUMORS; BRAIN; CHEMORADIATION; CONCOMITANT; CHEMORADIOTHERAPY Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15029