Universität zu Köln

Boschert, Alessa L., Elmenhorst, David, Gauger, Peter, Li, Zhili, Garcia-Gutierrez, Maria T., Gerlach, Darius ORCID: 0000-0001-7044-6065, Johannes, Bernd, Zange, Jochen, Bauer, Andreas and Rittweger, Jorn ORCID: 0000-0002-2223-8963 (2019). Sleep Is Compromised in-12 degrees Head Down Tilt Position. Front. Physiol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-042X

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Abstract

Recent studies are elucidating the interrelation between sleep, cranial perfusion, and cerebrospinal fluid (CSF) circulation. Head down tilt (HDT) as a simulation of microgravity reduces cranial perfusion. Therefore, our aim was to assess whether HDT is affecting sleep (clinicaltrials.gov; identifier NCT 02976168). 11 male subjects were recruited for a cross-over designed study. Each subject participated in two campaigns each comprising 3 days and 2 nights. Intervention started on the second campaign day and consisted of maintenance of horizontal position or -12 degrees HDT for 21 h. Ultrasound measurements were performed before, at the beginning and the end of intervention. Polysomnographic measurements were assessed in the second night which was either spent in horizontal posture or at -12 degrees HDT. Endpoints were sleep efficiency, sleep onset latency, number of sleep state changes and arousals, percentages of N3, REM, light sleep stages and subjective sleep parameters. N3 and REM sleep reduced by 25.6 and 19.1 min, respectively (P = 0.002, g = -0.898; P = 0.035, g = -0.634) during -12 degrees HDT. Light sleep (N1/2) increased by 33.0 min at -12 degrees HDT (P = 0.002, g = 1.078). On a scale from 1 to 9 subjective sleep quality deteriorated by 1.3 points during -12 degrees HDT (P = 0.047, g = -0.968). Ultrasonic measurement of the venous system showed a significant increase of the minimum (P = 0.009, P < 0.001) and maximum (P = 0.004, P = 0.002) cross-sectional area of the internal jugular vein at -12 degrees HDT. The minimum cross-sectional area of the external jugular vein differed significantly between conditions over time (P = 0.001) whereas frontal skin tissue thickness was not significantly different between conditions (P = 0.077, P = 0.811). Data suggests venous congestion at -12 degrees HDT. Since subjects felt comfortable with lying in -12 degrees HDT under our experimental conditions, this posture only moderately deteriorates sleep. Obviously, the human body can almost compensate the several fold effects of gravity in HDT posture like an affected CSF circulation, airway obstruction, unusual patterns of propioception and effects on the cardiovascular system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boschert, Alessa L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Zhili UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Gutierrez, Maria T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerlach, Darius UNSPECIFIED orcid.org/0000-0001-7044-6065 UNSPECIFIED Johannes, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Zange, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Jorn UNSPECIFIED orcid.org/0000-0002-2223-8963 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150667
DOI:	10.3389/fphys.2019.00397
Journal or Publication Title:	Front. Physiol.
Volume:	10
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-042X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE SIMULATED MICROGRAVITY; CIRCADIAN-RHYTHMS; BED REST; NOCTURNAL SLEEP; MOOD-STATE; PERFORMANCE; DEPRESSION; DRUGS; APNEA; POLYSOMNOGRAPHY Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15066