Universität zu Köln

Meyer, Melissa M., Haneder, Stefan, Konstandin, Simon, Budjan, Johannes, Morelli, John N., Schad, Lothar R., Kerl, Hans U., Schoenberg, Stefan O. and Kabbasch, Christoph (2019). Repeatability and reproducibility of cerebral Na-23 imaging in healthy subjects. BMC Med. Imag., 19. LONDON: BMC. ISSN 1471-2342

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Abstract

BackgroundInitial reports of Na-23 magnetic resonance imaging (MRI) date back to the 1970s. However, methodological challenges of the technique hampered its widespread adoption for many years. Recent technical developments have overcome some of these limitations and have led to more optimal conditions for Na-23-MR imaging. In order to serve as a reliable tool for the assessment of clinical stroke or brain tumor patients, we investigated the repeatability and reproducibility of cerebral sodium (Na-23) imaging in healthy subjects.MethodsIn this prospective, IRB approved study 12 consecutive healthy volunteers (8 female, age 318.3) underwent three cerebral Na-23-MRI examinations at 3.0T (TimTrio, Siemens Healthineers) distributed between two separate visits with an 8day interval. For each scan a T1w MP-RAGE sequence for anatomical referencing and a 3D-density-adapted, radial GRE-sequence for Na-23-imaging were acquired using a dual-tuned (Na-23/H-1) head-coil. On 1day, these scans were repeated consecutively; on the other day, the scans were performed once. Na-23-sequences were reconstructed according to the MP-RAGE sequence, allowing direct cross-referencing of ROIs. Circular ROIs were placed in predetermined anatomic regions: gray and white matter (GM, WM), head of the caudate nucleus (HCN), pons, and cerebellum. External Na-23-reference phantoms were used to calculate the tissue sodium content.ResultsExcellent correlation was found between repeated measurements on the same day (r(2)=0.94), as well as on a different day (r(2)=0.86). No significant differences were found based on laterality other than in the HCN (63.1 vs. 58.7mmol/kg WW on the right (p=0.01)). Pronounced inter-individual differences were identified in all anatomic regions. Moderate to good correlation (0.310 to 0.701) was found between the readers.Conclusion Our study has shown that intra-individual Na-23-concentrations in healthy subjects do not significantly differ after repeated scans on the same day and a pre-set time interval. This confirms the repeatability and reproducibility of cerebral Na-23-imaging. However, with manual ROI placement in predetermined anatomic landmarks, fluctuations in Na-23-concentrations can be observed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Melissa M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Konstandin, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Budjan, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Morelli, John N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schad, Lothar R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kerl, Hans U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenberg, Stefan O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-151080
DOI:	10.1186/s12880-019-0324-6
Journal or Publication Title:	BMC Med. Imag.
Volume:	19
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2342
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TISSUE SODIUM CONCENTRATION; MAGNETIC-RESONANCE; HUMAN-BRAIN; HUMAN KIDNEY; IN-VIVO; 3 T; MRI; RELAXATION; MANAGEMENT; STROKE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15108