Hopfner, Franziska ORCID: 0000-0001-6524-0281, Mueller, Stefanie H., Steppat, Dagmar, Miller, Joanna, Schmidt, Nele, Wandinger, Klaus-Peter, Leypoldt, Frank, Berg, Daniela, Franke, Andre, Lieb, Wolfgang, Tittmann, Lukas, Balzer-Geldsetzer, Monika, Baudrexel, Simon, Dodel, Richard, Hilker-Roggendorf, Ruediger, Kalbe, Elke, Kassubek, Jan ORCID: 0000-0002-7106-9270, Klockgether, Thomas, Liepelt-Scarfone, Inga, Mollenhauer, Brit, Neuser, Petra, Reetz, Kathrin, Riedel, Oliver, Schulte, Claudia ORCID: 0000-0003-4006-1265, Schulz, Joerg B., Spottke, Annika, Storch, Alexander, Trenkwalder, Claudia, Wittchen, Hans-Ulrich, Witt, Karsten, Wuellner, Ullrich, Deuschl, Gunther ORCID: 0000-0002-4176-9196 and Kuhlenbaeumer, Gregor (2019). No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors. Transl. Neurodegener., 8. LONDON: BMC. ISSN 2047-9158

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Abstract

Background: IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (n = 296) and controls (n = 295) free of neuropsychiatric disease. Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment. Methods: NMDA antibodies were analysed in the serum of patients and controls using well established validated assays. We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics. Results: The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients (13%) than in controls (22%) and higher than in previous studies in both groups. NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment, nor with quantitative indicators of disease severity and cognitive impairment A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients. Conclusion: It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g. to Parkinson disease with dementia, while NMDA IgG antibodies define a separate disease of its own.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hopfner, FranziskaUNSPECIFIEDorcid.org/0000-0001-6524-0281UNSPECIFIED
Mueller, Stefanie H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steppat, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miller, JoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, NeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wandinger, Klaus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leypoldt, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lieb, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittmann, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzer-Geldsetzer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baudrexel, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker-Roggendorf, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Klockgether, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuser, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reetz, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, ClaudiaUNSPECIFIEDorcid.org/0000-0003-4006-1265UNSPECIFIED
Schulz, Joerg B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuellner, UllrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuntherUNSPECIFIEDorcid.org/0000-0002-4176-9196UNSPECIFIED
Kuhlenbaeumer, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-151104
DOI: 10.1186/s40035-019-0153-0
Journal or Publication Title: Transl. Neurodegener.
Volume: 8
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 2047-9158
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COGNITIVE IMPAIRMENT; DEMENTIAMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15110

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