Universität zu Köln

Kim, Austin, I, Goergen, Helen, Engert, Andreas, LaCasce, Ann S., Maranda, Louise, Barton, Bruce and Borchmann, Sven (2019). Suicide in European Hodgkin Lymphoma Patients. Hemasphere, 3 (2). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2572-9241

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Abstract

The purpose of this study was to determine whether there is an increased risk of suicide in European Hodgkin Lymphoma (HL) patients compared to the general European population. European HL patients enrolled in the German Hodgkin Study Group (GHSG) HD7 through HD15 studies were analyzed and standardized mortality ratio (SMR) was calculated using suicide mortality rates for the general European population. Case-control analysis was performed to identify characteristics associated with risk of death by suicide. Among 12,202 European HL patients observed for 94,972 person-years, 19 suicides (17 males and 2 females) were identified resulting in a SMR 1.63 (95% CI: 1.01-2.50, p=0.046). The only characteristic associated with a statistically significant increased risk of suicide was male sex with an odds ratio (OR) 8.42 (95% CI=1.04-67.85; p=0.046) on multivariate analysis. These findings were confirmed in an independently analyzed Surveillance, Epidemiology, and End Results Program (SEER) validation dataset. European HL patients have a significantly increased incidence of suicide compared to the general European population. Male HL patients have a greater than 8-fold increased risk of suicide compared to female HL patients. Further study of social risk factors associated with an increased risk of suicide in HL patients is needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kim, Austin, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergen, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED LaCasce, Ann S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maranda, Louise UNSPECIFIED UNSPECIFIED UNSPECIFIED Barton, Bruce UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-151220
DOI:	10.1097/HS9.0000000000000183
Journal or Publication Title:	Hemasphere
Volume:	3
Number:	2
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2572-9241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVOLVED-FIELD RADIOTHERAPY; FINAL ANALYSIS; OPEN-LABEL; CHEMOTHERAPY; DACARBAZINE; INTENSITY; BLEOMYCIN; CANCER; CYCLES; TRIAL Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15122