Universität zu Köln

Shi-Kunne, Xiaoqian, Jove, Roger de Pedro, Depotter, Jasper R. L., Ebert, Malaika K., Seidl, Michael F. and Thomma, Bart P. H. J. ORCID: 0000-0003-4125-4181 (2019). In silico prediction and characterisation of secondary metabolite clusters in the plant pathogenic fungus Verticillium dahliae. FEMS Microbiol. Lett., 366 (7). OXFORD: OXFORD UNIV PRESS. ISSN 1574-6968

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Abstract

Fungi are renowned producers of natural compounds, also known as secondary metabolites (SMs) that display a wide array of biological activities. Typically, the genes that are involved in the biosynthesis of SMs are located in close proximity to each other in so-called secondary metabolite clusters. Many plant-pathogenic fungi secrete SMs during infection in order to promote disease establishment, for instance as cytocoxic compounds. Verticillium dahliae is a notorious plant pathogen that can infect over 200 host plants worldwide. However, the SM repertoire of this vascular pathogen remains mostly uncharted. To unravel the potential of V. dahliae to produce SMs, we performed in silico predictions and in-depth analyses of its secondary metabolite clusters. Using distinctive traits of gene clusters and the conserved signatures of core genes 25 potential SM gene clusters were identified. Subsequently, phylogenetic and comparative genomics analyses were performed, revealing that two putative siderophores, ferricrocin and TAFC, DHN-melanin and fujikurin may belong to the SM repertoire of V. dahliae.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shi-Kunne, Xiaoqian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jove, Roger de Pedro UNSPECIFIED UNSPECIFIED UNSPECIFIED Depotter, Jasper R. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebert, Malaika K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidl, Michael F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomma, Bart P. H. J. UNSPECIFIED orcid.org/0000-0003-4125-4181 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-151425
DOI:	10.1093/femsle/fnz081
Journal or Publication Title:	FEMS Microbiol. Lett.
Volume:	366
Number:	7
Date:	2019
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1574-6968
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOSYNTHETIC GENE-CLUSTER; DIFFERENTIAL EXPRESSION ANALYSIS; MAGNAPORTHE-GRISEA; IDENTIFICATION; TOOL; VIRULENCE; EVOLUTION; DISTINCT; MELANIN Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15142