Universität zu Köln

Zepf, Florian D., Bubenzer-Busch, Sarah, Runions, Kevin C., Rao, Pradeep, Wong, Janice W. Y., Mahfouda, Simone, Morandini, Hugo A. E., Stewart, Richard M., Moore, Julia K., Biskup, Caroline S., Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Langner, Robert ORCID: 0000-0002-3237-001X (2019). Functional connectivity of the vigilant-attention network in children and adolescents with attention-deficit/hyperactivity disorder. Brain Cogn., 131. S. 56 - 66. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2147

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Abstract

The ability to maintain attention to simple tasks (i.e., vigilant attention, VA) is often impaired in attention-deficit/hyperactivity disorder (ADHD), but the underlying pathophysiological mechanisms at the brain network level are not clear yet. We therefore investigated ADHD-related differences in resting-state functional connectivity within a meta-analytically defined brain network of 14 distinct regions subserving VA (comprising 91 connections in total), as well as the association of connectivity with markers of behavioural dysfunction in 17 children (age range: 9-14 years) with a diagnosis of ADHD and 21 age-matched neurotypical controls. Our analyses revealed selective, rather than global, differences in the intrinsic coupling between nodes of the VA-related brain network in children with ADHD, relative to controls. In particular, ADHD patients showed substantially diminished intrinsic coupling for 7 connections and increased coupling for 4 connections, with many differences involving connectivity with the anterior insula. Moreover, connectivity strength of several aberrant connections was found to be associated with core aspects of ADHD symptomatology, such as poor attention, difficulties with social functioning, and impaired cognitive control, attesting to the behavioural relevance of specific connectivity differences observed in the resting state.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zepf, Florian D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bubenzer-Busch, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Runions, Kevin C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rao, Pradeep UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, Janice W. Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahfouda, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Morandini, Hugo A. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stewart, Richard M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moore, Julia K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Biskup, Caroline S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Langner, Robert UNSPECIFIED orcid.org/0000-0002-3237-001X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-152209
DOI:	10.1016/j.bandc.2017.10.005
Journal or Publication Title:	Brain Cogn.
Volume:	131
Page Range:	S. 56 - 66
Date:	2019
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2147
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT HYPERACTIVITY DISORDER; RIGHT-HEMISPHERE DYSFUNCTION; SUSTAINED ATTENTION; CONCURRENT VALIDITY; BEHAVIOR CHECKLIST; PREFRONTAL CORTEX; DEFAULT MODE; BRAIN; ADHD; ACTIVATION Multiple languages Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15220