Universität zu Köln

Stecher, Melanie, Schommers, Philipp ORCID: 0000-0003-3375-6800, Schmidt, Daniel, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, Lehmann, Clara, Platten, Martin, Faetkenheuer, Gerd and Vehreschild, Joerg Janne (2019). Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016. Infection, 47 (2). S. 247 - 256. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

PurposeThe aim of the study was to assess guideline adherence to combined antiretroviral therapy (ART) in the German ClinSurv HIV Cohort and the real-life impact of the Strategic Timing of Antiretroviral Therapy (START) study, to identify patients not treated as recommended by new guidelines.MethodsWe used data from the multicenter ClinSurv cohort of the Robert-Koch-Institute (RKI) between 1999 and 2016. Inclusion criteria were people living with HIV/AIDS, 18years of age and cART naive at the first visit (FV). Adherence was defined as starting cART within 6 months of crossing the CD4(+) T cell threshold as suggested by the German-Austrian treatment guidelines. Logistic regression was used to identify factors associated with non-adherence.Results11,817 patients met the inclusion criteria. We observed an overall adherence rate of 60%, in patients with treatment indication who started cART timely between 2002 and 2015. Adherence rate increased constantly, demonstrating a potential increase in patients, with treatment indication, starting cART within 6 months of presentation from 55% in 2008 to 94% in 2015. Patients reporting injection drug use (OR 2.18, 95% CI 1.70-2.95) and patients between 18years and 39years of age at the time of their first visit (OR 2.89, 95% CI 1.35-6.18) were identified as risk groups associated with non-adherence.ConclusionThe majority of patients below the CD4(+) T cell count threshold of applicable guidelines initiated treatment within 6 months. We observed a slowly diminishing proportion of patients not starting cART timely. Delayed treatment was more frequent in patients reporting injection drug use.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stecher, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Schmidt, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kollan, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gunsenheimer-Bartmeyer, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Platten, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Joerg Janne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-152458
DOI:	10.1007/s15010-018-1248-8
Journal or Publication Title:	Infection
Volume:	47
Number:	2
Page Range:	S. 247 - 256
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Mathematics and Computer Science > Institute of Computer Science
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTEMATIC ANALYSIS; GLOBAL BURDEN; THERAPY; INJURIES; DISEASES; RISK Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15245