Universität zu Köln

Zittermann, A., Ernst, J. B., Prokop, S., Fuchs, U., Gruszka, A., Dreier, J., Kuhn, J., Knabbe, C., Berthold, H. K., Gouni-Berthold, I, Pilz, S., Gummert, J. F. and Paluszkiewicz, L. (2019). Vitamin D supplementation of 4000 IU daily and cardiac function in patients with advanced heart failure: The EVITA trial. Int. J. Cardiol., 280. S. 117 - 124. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Background: Data regarding the effects of vitamin D on cardiac function are inconclusive. Methods: In a post-hoc analysis of the EVITA (Effect of vitamin D on mortality in heart failure) trial, we investigated whether a daily vitamin D-3 supplement of 4000 IU for three years affects echocardiography parameters like left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), and LV ejection fraction (LVEF) in patients with advanced heart failure (HF) and 25-hydroxyvitamin D levels <75 nmol/L. Of 400 patients enrolled, 199 were assigned to vitamin D and 201 to placebo. We assessed time x treatment interaction effects using linear mixed models and analyzed in subgroups vitamin D effects at 12 and 36 months postrandomization using analysis of covariance with adjustments for baseline values. Results: At baseline, values of LVEDD, LVESD, and LVEF were 67.5 +/- 10.5mm, 58.9 +/- 12.0mm, and 30.47 +/- 10.2%, respectively. There were no time x treatment interaction effects on LV echocardiographic parameters in the entire study cohort, neither at 12months nor at 36 months post-randomization (P-values > 0.05). However, in the subgroup of patients aged >= 50 years, vitamin D treatment was associated with an increase in LVEF of 2.73% (95% CI: 0.14 to 5.31%) at 12 months post-randomization (n =311). The increase was slightly attenuated to 2.60% (95% CI:-2.47 to 7.67%) at 36 months post-randomization (n=242). Conclusion: Our data indicate that vitamin D supplementation does not significantly improve cardiac function in all patientswith advanced HF. However, vitamin D probably improves LV function in HF patients aged =50 years. (c) 2019 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zittermann, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, J. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruszka, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreier, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knabbe, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, H. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gummert, J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paluszkiewicz, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-153217
DOI:	10.1016/j.ijcard.2019.01.027
Journal or Publication Title:	Int. J. Cardiol.
Volume:	280
Page Range:	S. 117 - 124
Date:	2019
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language D DEFICIENCY; DOUBLE-BLIND; ASSOCIATION; 1,25-DIHYDROXYVITAMIN-D; ECHOCARDIOGRAPHY; METAANALYSIS; SOCIETY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15321