Universität zu Köln

Jabbari, Kamel, Wirtz, Johannes, Rauscher, Martina and Wiehe, Thomas ORCID: 0000-0002-8932-2772 (2019). A common genomic code for chromatin architecture and recombination landscape. PLoS One, 14 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Recent findings established a link between DNA sequence composition and interphase chromatin architecture and explained the evolutionary conservation of TADs (Topologically Associated Domains) and LADs (Lamina Associated Domains) in mammals. This prompted us to analyse conformation capture and recombination rate data to study the relationship between chromatin architecture and recombination landscape of human and mouse genomes. The results reveal that: (1) low recombination domains and blocks of elevated linkage disequilibrium tend to coincide with TADs and isochores, indicating co-evolving regulatory elements and genes in insulated neighbourhoods; (2) double strand break (DSB) and recombination frequencies increase in the short loops of GC-rich TADs, whereas recombination cold spots are typical of LADs and (3) the binding and loading of proteins, which are critical for DSB and meiotic recombination (SPO11, DMC1, H3K4me3 and PRMD9) are higher in GC-rich TADs. One explanation for these observations is that the occurrence of DSB and recombination in meiotic cells are associated with compositional and epigenetic features (genomic code) that influence DNA stiffness/flexibility and appear to be similar to those guiding the chromatin architecture in the interphase nucleus of pre-leptotene cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jabbari, Kamel UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauscher, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiehe, Thomas UNSPECIFIED orcid.org/0000-0002-8932-2772 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-153846
DOI:	10.1371/journal.pone.0213278
Journal or Publication Title:	PLoS One
Volume:	14
Number:	3
Date:	2019
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIASED GENE CONVERSION; STRAND BREAK FORMATION; MEIOTIC RECOMBINATION; LINKAGE DISEQUILIBRIUM; MAMMALIAN GENOMES; REVEALS; RICH; DNA; FEATURES; REPAIR Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15384