Bacher, Petra, Hohnstein, Thordis, Beerbaum, Eva, Roecker, Marie, Blango, Matthew G., Kaufmann, Svenja, Roehmel, Jobst, Eschenhagen, Patience, Grehn, Claudia, Seidel, Kathrin, Rickerts, Volker, Lozza, Laura, Stervbo, Ulrik ORCID: 0000-0002-2831-8868, Nienen, Mikalai ORCID: 0000-0002-5678-1956, Babel, Nina ORCID: 0000-0003-3673-712X, Milleck, Julia, Assenmacher, Mario, Cornely, Oliver A., Ziegler, Maren, Wisplinghoff, Hilmar, Heine, Guido, Worm, Margitta, Siegmund, Britta, Maul, Jochen ORCID: 0000-0002-1323-0150, Creutz, Petra, Tabeling, Christoph, Ruwwe-Gloesenkamp, Christoph, Sander, Leif E., Knosalla, Christoph, Brunke, Sascha ORCID: 0000-0001-7740-4570, Hube, Bernhard, Kniemeyer, Olaf ORCID: 0000-0002-9493-6402, Brakhage, Axel A., Schwarz, Carsten and Scheffold, Alexander ORCID: 0000-0002-0626-343X (2019). Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell, 176 (6). S. 1340 - 1371. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

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Abstract

Th17 cells provide protection at barrier tissues but may also contribute to immune pathology. The relevance and induction mechanisms of pathologic Th17 responses in humans are poorly understood. Here, we identify the mucocutaneous pathobiont Candida albicans as the major direct inducer of human anti-fungal Th17 cells. Th17 cells directed against other fungi are induced by cross-reactivity to C. albicans. Intestinal inflammation expands total C. albicans and cross-reactive Th17 cells. Strikingly, Th17 cells cross-reactive to the airborne fungus Aspergillus fumigatus are selectively activated and expanded in patients with airway inflammation, especially during acute allergic bronchopulmonary aspergillosis. This indicates a direct link between protective intestinal Th17 responses against C. albicans and lung inflammation caused by airborne fungi. We identify heterologous immunity to a single, ubiquitous member of the microbiota as a central mechanism for systemic induction of human antifungal Th17 responses and as a potential risk factor for pulmonary inflammatory diseases.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bacher, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hohnstein, ThordisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beerbaum, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roecker, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blango, Matthew G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roehmel, JobstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eschenhagen, PatienceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grehn, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rickerts, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lozza, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stervbo, UlrikUNSPECIFIEDorcid.org/0000-0002-2831-8868UNSPECIFIED
Nienen, MikalaiUNSPECIFIEDorcid.org/0000-0002-5678-1956UNSPECIFIED
Babel, NinaUNSPECIFIEDorcid.org/0000-0003-3673-712XUNSPECIFIED
Milleck, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Assenmacher, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, MarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wisplinghoff, HilmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heine, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, MargittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegmund, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maul, JochenUNSPECIFIEDorcid.org/0000-0002-1323-0150UNSPECIFIED
Creutz, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabeling, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruwwe-Gloesenkamp, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sander, Leif E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knosalla, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunke, SaschaUNSPECIFIEDorcid.org/0000-0001-7740-4570UNSPECIFIED
Hube, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kniemeyer, OlafUNSPECIFIEDorcid.org/0000-0002-9493-6402UNSPECIFIED
Brakhage, Axel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffold, AlexanderUNSPECIFIEDorcid.org/0000-0002-0626-343XUNSPECIFIED
URN: urn:nbn:de:hbz:38-154124
DOI: 10.1016/j.cell.2019.01.041
Journal or Publication Title: Cell
Volume: 176
Number: 6
Page Range: S. 1340 - 1371
Date: 2019
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4172
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CD4(+) T-CELLS; ASPERGILLUS-FUMIGATUS; CYSTIC-FIBROSIS; T(H)17 CELLS; FUNGAL; IDENTIFICATION; SPECIFICITY; AUTOIMMUNITY; PHENOTYPE; PRODUCEMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15412

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