Schuepbach, W. M. Michael, Tonder, Lisa, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Krack, Paul ORCID: 0000-0002-3508-7295, Rau, Joern, Hartmann, Andreas, Haelbig, Thomas D., Pineau, Fanny, Falk, Andrea, Paschen, Laura, Paschen, Stephen, Volkmann, Jens, Dafsari, Haidar S., Barbe, Michael T., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kuehn, Andrea, Kupsch, Andreas, Schneider, Gerd-H, Seigneuret, Eric, Fraix, Valerie, Kistner, Andrea, Chaynes, P. Patrick, Ory-Magne, Fabienne, Brefel-Courbon, Christine, Vesper, Jan, Wojtecki, Lars, Derrey, Stephane, Maltete, David, Damier, Philippe, Derkinderen, Pascal, Sixel-Doering, Friederike, Trenkwalder, Claudia, Gharabaghi, Alireza, Waechter, Tobias, Weiss, Daniel, Pinsker, Marcus O., Regis, Jean-Marie, Witjas, Tatiana, Thobois, Stephane, Mertens, Patrick, Knudsen, Karina, Schade-Brittinger, Carmen, Houeto, Jean-Luc, Agid, Yves, Vidailhet, Marie, Timmermann, Lars and Deuschl, Guenther (2019). Quality of life predicts outcome of deep brain stimulation in early Parkinson disease. Neurology, 92 (10). S. E1109 - 12. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X

Full text not available from this repository.

Abstract

Objective To investigate predictors for improvement of disease-specific quality of life (QOL) after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson disease (PD) with early motor complications. Methods We performed a secondary analysis of data from the previously published EARLYSTIM study, a prospective randomized trial comparing STN-DBS (n = 124) to best medical treatment (n = 127) after 2 years follow-up with disease-specific QOL (39-item Parkinson's Disease Questionnaire summary index [PDQ-39-SI]) as the primary endpoint. Linear regression analyses of the baseline characteristics age, disease duration, duration of motor complications, and disease severity measured at baseline with the Unified Parkinson's Disease Rating Scale (UPDRS) (UPDRS-III off and on medications, UPDRS-IV) were conducted to determine predictors of change in PDQ-39-SI. Results PDQ-39-SI at baseline was correlated to the change in PDQ-39-SI after 24 months in both treatment groups (p < 0.05). The higher the baseline score (worse QOL) the larger the improvement in QOL after 24 months. No correlation was found for any of the other baseline characteristics analyzed in either treatment group. Conclusion Impaired QOL as subjectively evaluated by the patient is the most important predictor of benefit in patients with PD and early motor complications, fulfilling objective gold standard inclusion criteria for STN-DBS. Our results prompt systematically including evaluation of disease-specific QOL when selecting patients with PD for STN-DBS. Clinicaltrials.gov identifier NCT00354133.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schuepbach, W. M. MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tonder, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDorcid.org/0000-0002-6414-7939UNSPECIFIED
Krack, PaulUNSPECIFIEDorcid.org/0000-0002-3508-7295UNSPECIFIED
Rau, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haelbig, Thomas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pineau, FannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falk, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Kuehn, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupsch, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, Gerd-HUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seigneuret, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fraix, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kistner, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaynes, P. PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ory-Magne, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brefel-Courbon, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesper, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wojtecki, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derrey, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maltete, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derkinderen, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sixel-Doering, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gharabaghi, AlirezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waechter, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinsker, Marcus O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regis, Jean-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witjas, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thobois, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mertens, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knudsen, KarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schade-Brittinger, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houeto, Jean-LucUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agid, YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidailhet, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuentherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-154187
DOI: 10.1212/WNL.0000000000007037
Journal or Publication Title: Neurology
Volume: 92
Number: 10
Page Range: S. E1109 - 12
Date: 2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1526-632X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBTHALAMIC NUCLEUS STIMULATION; MEDICAL THERAPY; NEUROSTIMULATION; TRIAL; STAGEMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15418

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item