Thanarajah, Sharmili Edwin, Pruess, Harald, Warnke, Clemens, Barbe, Michael T., Schroeter, Michael, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Onur, Oezguer A. (2019). Atypical Autoimmune Encephalitis With Neuropil Antibodies Against a Yet Unknown Epitope. Front. Neurol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-2295

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Abstract

Autoimmune encephalitis often causes acute psychiatric symptoms and epileptic seizures. However, it is becoming increasingly clear that depending on the target antigen both symptoms and disease severity may vary. Furthermore, the identification and characterization of antibody subtypes are highly relevant for personalizing the treatment and to prevent relapses. Here we present an atypical case of encephalitis with cerebellar and temporal dysfunction but without seizures associated with high levels of cerebrospinal fluid neuropil antibodies against a yet unknown epitope on the neuronal surface in the cerebellum, hippocampus, thalamus, and the olfactory bulb. We treated the patient successfully with corticosteroids, plasmapheresis, and rituximab.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Thanarajah, Sharmili EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pruess, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Onur, Oezguer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-154227
DOI: 10.3389/fneur.2019.00175
Journal or Publication Title: Front. Neurol.
Volume: 10
Date: 2019
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-2295
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Clinical Neurology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15422

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