Gras, Luuk, May, Margaret, Ryder, Lars Peter, Trickey, Adam ORCID: 0000-0003-3462-2898, Helleberg, Marie, Obel, Niels, Thiebaut, Rodolphe, Guest, Jodie, Gill, John, Crane, Heidi, Lima, Viviane Dias, Monforte, Antonella d'Arminio, Sterling, Timothy R., Miro, Jose, Moreno, Santiago, Stephan, Christoph, Smith, Colette ORCID: 0000-0003-2847-3355, Tate, Janet, Shepherd, Leah, Saag, Mike, Rieger, Armin, Gillor, Daniel, Cavassini, Matthias, Montero, Marta ORCID: 0000-0002-3432-5394, Ingle, Suzanne M., Reiss, Peter, Costagliola, Dominique ORCID: 0000-0003-0765-0869, Wit, Ferdinand W. N. M., Sterne, Jonathan ORCID: 0000-0001-8496-6053, de Wolf, Frank, Geskus, Ronald, Boulle, Andrew, Stephan, Christoph, Miro, Jose M., Cavassini, Matthias, Chene, Genevieve, Costagliola, Dominique ORCID: 0000-0003-0765-0869, Dabis, Francois, Monforte, Antonella d'Arminio, del Amo, Julia, van Sighem, Ard, Vehreschild, Jorg-Janne, Gill, John, Guest, Jodie, Haerry, David Hans-Ulrich, Hogg, Robert, Justice, Amy, Shepherd, Leah, Obel, Niels, Crane, Heidi M., Smith, Colette ORCID: 0000-0003-2847-3355, Reiss, Peter, Saag, Michael, Sterling, Tim, Teira, Ramon, Williams, Matthew, Zangerle, Robert, Sterne, Jonathan ORCID: 0000-0001-8496-6053, May, Margaret, Ingle, Suzanne and Trickey, Adam ORCID: 0000-0003-3462-2898 (2019). Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy. JAIDS, 80 (3). S. 292 - 301. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1077-9450

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Abstract

Background: An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4: CD8 ratio during virologically suppressive ART to median levels seen in HIV-uninfected individuals more likely and whether restoration depends on gender, age, and other individual characteristics. Methods: We determined median and quartile reference values for CD4 and CD8 cell counts and their ratio using cross-sectional data from 2309 HIV-negative individuals. We used longitudinal measurements of 60,997 HIV-positive individuals from the Antiretroviral Therapy Cohort Collaboration in linear mixed-effects models. Results: When baseline CD4 cell counts were higher, higher long-term CD4 cell counts and CD4: CD8 ratios were reached. Highest long-term CD4 cell counts were observed in middle-aged individuals. During the first 2 years, median CD8 cell counts converged toward median reference values. However, changes were small thereafter and long-term CD8 cell count levels were higher than median reference values. Median 8-year CD8 cell counts were higher when ART was started with,250 CD4 cells/mm(3). Median CD4: CD8 trajectories did not reach median reference values, even when ART was started at 500 cells/mm(3). Discussion: Starting ART with a CD4 cell count of >= 500 cells/mm3 makes reaching median reference CD4 cell counts more likely. However, median CD4: CD8 ratio trajectories remained below the median levels of HIV-negative individuals because of persisting high CD8 cell counts. To what extent these subnormal immunological responses affect specific clinical endpoints requires further investigation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gras, LuukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryder, Lars PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trickey, AdamUNSPECIFIEDorcid.org/0000-0003-3462-2898UNSPECIFIED
Helleberg, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiebaut, RodolpheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guest, JodieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crane, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lima, Viviane DiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella d'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterling, Timothy R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreno, SantiagoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephan, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
Tate, JanetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shepherd, LeahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saag, MikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieger, ArminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gillor, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavassini, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montero, MartaUNSPECIFIEDorcid.org/0000-0002-3432-5394UNSPECIFIED
Ingle, Suzanne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costagliola, DominiqueUNSPECIFIEDorcid.org/0000-0003-0765-0869UNSPECIFIED
Wit, Ferdinand W. N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterne, JonathanUNSPECIFIEDorcid.org/0000-0001-8496-6053UNSPECIFIED
de Wolf, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geskus, RonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boulle, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephan, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, Jose M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavassini, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chene, GenevieveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costagliola, DominiqueUNSPECIFIEDorcid.org/0000-0003-0765-0869UNSPECIFIED
Dabis, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella d'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Amo, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Sighem, ArdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Jorg-JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guest, JodieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haerry, David Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogg, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Justice, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shepherd, LeahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crane, Heidi M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saag, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterling, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teira, RamonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterne, JonathanUNSPECIFIEDorcid.org/0000-0001-8496-6053UNSPECIFIED
May, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingle, SuzanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trickey, AdamUNSPECIFIEDorcid.org/0000-0003-3462-2898UNSPECIFIED
URN: urn:nbn:de:hbz:38-154467
DOI: 10.1097/QAI.0000000000001913
Journal or Publication Title: JAIDS
Volume: 80
Number: 3
Page Range: S. 292 - 301
Date: 2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1077-9450
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LYMPHOCYTE SUBSETS; CD4/CD8 RATIO; 1-INFECTED PATIENTS; REFERENCE RANGES; REFERENCE VALUES; HIV-INFECTION; AGE; NAIVE; RECOVERY; BLOODMultiple languages
Immunology; Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15446

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