Universität zu Köln

Cairo, Beatrice, De Maria, Beatrice, Bari, Vlasta ORCID: 0000-0002-5346-2677, Vaini, Emanuele ORCID: 0000-0001-5873-6609, Heusser, Karsten, Tank, Jens, Jordan, Jens, Barbic, Franca, Furlan, Raffaello, Marinou, Kalliopi, Dalla Vecchia, Laura and Porta, Alberto (2019). Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients. Physiol. Meas., 40 (3). BRISTOL: IOP PUBLISHING LTD. ISSN 1361-6579

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Abstract

Background: The sympathetic baroreflex (sBR) adjusts muscle sympathetic nerve activity (MSNA) in response to arterial pressure changes but the relevance of assessing sBR control complexity is unclear. Objective We propose a method for the evaluation of sBR control complexity. Approach: The approach comprises the quantification of complexity of the sBR latency regulation and the assessment of complexity of the relationship linking MSNA burst to R-wave peak regardless of the variability of the sBR latency. The Shannon entropy (SE) of the sBR latency distribution is taken as an estimate of complexity of the sBR latency regulation. The conditional entropy (CE) of the beatto-beat binary series obtained by coding the presence/absence of the MSNA burst after an R-wave peak is taken as an estimate of complexity of the sBR control regardless of the sBR latency variability. Surrogate analysis was utilized to set the level of inactive or impaired sBR. The approach was applied to 10 young healthy subjects undergoing head-up tilt (HUT) followed by lower body negative pressure to evoke presyncope (preSYNC) before and after 21 d head-down bed rest (HDBR), and to five amyotrophic lateral sclerosis (ALS) patients undergoing HUT. Main results: In healthy subjects the surrogate analysis suggested that HUT and preSYNC significantly activated the sBR control but its response was weakened after 21 d HDBR. During preSYNC sBR latency increased significantly only after 21 d HDBR. In ALS patients the complexity of the sBR latency regulation was close to the level set by surrogate analysis and HUT did not trigger any sBR control response. Significance: The proposed method for sBR control complexity quantification was useful in detecting the impairment of the sBR control after 21 d HDBR in healthy subjects and the dysfunction of the sBR regulation in ALS patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cairo, Beatrice UNSPECIFIED UNSPECIFIED UNSPECIFIED De Maria, Beatrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Bari, Vlasta UNSPECIFIED orcid.org/0000-0002-5346-2677 UNSPECIFIED Vaini, Emanuele UNSPECIFIED orcid.org/0000-0001-5873-6609 UNSPECIFIED Heusser, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbic, Franca UNSPECIFIED UNSPECIFIED UNSPECIFIED Furlan, Raffaello UNSPECIFIED UNSPECIFIED UNSPECIFIED Marinou, Kalliopi UNSPECIFIED UNSPECIFIED UNSPECIFIED Dalla Vecchia, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Porta, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-154937
DOI:	10.1088/1361-6579/ab0d4b
Journal or Publication Title:	Physiol. Meas.
Volume:	40
Number:	3
Date:	2019
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1361-6579
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURAL RECRUITMENT STRATEGIES; NERVE ACTIVITY; VASOCONSTRICTOR NEURONS; STATIC HANDGRIP; HEART PERIOD; VARIABILITY; DISCHARGE; MODULATION; LATENCY; TILT Multiple languages Biophysics; Engineering, Biomedical; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15493