Universität zu Köln

Felcht, Moritz, Klemke, Claus-Detlev, Nicolay, Jan Peter, Weiss, Christel, Assaf, Chalid, Wobser, Marion, Schlaak, Max, Hillen, Uwe, Moritz, Rose, Tantcheva-Poor, Iliana, Nashan, Dorothee, Beyer, Marc, Dippel, Edgar, Mueller, Cornelia Sigrid Lissi, Sachse, Michael Max, Meiss, Frank, Geraud, Cyrill ORCID: 0000-0001-9432-6869, Marx, Alexander, Goerdt, Sergij, Geissinger, Eva and Kempf, Werner (2019). Primary cutaneous diffuse large B-cell lymphoma, NOS and leg type: Clinical, morphologic and prognostic differences. J. Dtsch. Dermatol. Ges., 17 (3). S. 275 - 286. HOBOKEN: WILEY. ISSN 1610-0387

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Abstract

Background and objectives : Primary cutaneous diffuse large B-cell lymphoma, NOS (PCLBCL/NOS) is a rare PCLBCL. Only few data are available for this tumor. The aim of this study was to identify clinical and/or immunohistochemical markers (in addition to Bcl-2) that characterize PCLBCL/NOS, assist in differentiating it from PCLBCL, leg type (PCLBCL/LT) and help to assess the clinical course/prognosis. Patients and methods : Bcl-2 -PCLBCL/NOS) cases (n = 14 were compared with Bcl-2(+) PCLBCL/LT cases (n = 29). Results : PCLBCL/NOS patients were younger, predominantly male and had better survival rates than patients with PCLBCL/LT. Patients with PCLBCL/NOS presented more often with larger plaques limited to one or two contiguous body regions, whereas PCLBCL/LT cases often presented with disseminated lesions. Neoplastic cells had a higher proliferation rate (Ki67) in PCLBCL/LT patients. The tumor microenvironment of PCLBCL/NOS had a more prominent CD3 + infiltrate. Overall survival data for the whole cohort (n = 37) revealed that female gender and Bcl-2 expression correlated with a worse survival rate. Bcl-6 expression and centroblastic subtype correlated with better outcomes. None of the other markers studied (e. g. GCB/non-GCB subtype) correlated with survival rate. Conclusions : PCLBCL/NOS and PCLBCL/LT differ in their clinical behavior and outcomes. Bcl-2 still seems to be the best marker for discriminating between these two subgroups. Bcl-2, female gender and Bcl-6 represent prognostic markers for PCLBCL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Felcht, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Klemke, Claus-Detlev UNSPECIFIED UNSPECIFIED UNSPECIFIED Nicolay, Jan Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Christel UNSPECIFIED UNSPECIFIED UNSPECIFIED Assaf, Chalid UNSPECIFIED UNSPECIFIED UNSPECIFIED Wobser, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillen, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Moritz, Rose UNSPECIFIED UNSPECIFIED UNSPECIFIED Tantcheva-Poor, Iliana UNSPECIFIED UNSPECIFIED UNSPECIFIED Nashan, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Dippel, Edgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Cornelia Sigrid Lissi UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachse, Michael Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Meiss, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Geraud, Cyrill UNSPECIFIED orcid.org/0000-0001-9432-6869 UNSPECIFIED Marx, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Goerdt, Sergij UNSPECIFIED UNSPECIFIED UNSPECIFIED Geissinger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Kempf, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-155087
DOI:	10.1111/ddg.13773
Journal or Publication Title:	J. Dtsch. Dermatol. Ges.
Volume:	17
Number:	3
Page Range:	S. 275 - 286
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1610-0387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHO-EORTC CLASSIFICATION; TREATMENT-OF-CANCER; CLINICOPATHOLOGICAL FEATURES; MYCOSIS-FUNGOIDES; GENE-EXPRESSION; SURVIVAL; SUBTYPES; ORIGIN; SYSTEM Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15508