Universität zu Köln

Hu, Haitao, Xue, Jin, Dong, Renshun, Zhao, Yanan, Song, Chunyan, Zhao, Hongjian, Hescheler, Juergen, Zhang, Yan and Liang, Huamin (2019). STAT3 Phosphorylation Mediating DMSO's Function on Fetal Cardiomyocyte Proliferation with Developmental Changes. Int. Heart J., 60 (2). S. 392 - 400. TOKYO: INT HEART JOURNAL ASSOC. ISSN 1349-3299

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Abstract

Endogenous cardiac regeneration has been focused for decades as a potential therapy for heart diseases with cell loss, and dimethyl sulfoxide (DMSO) has been proposed as a treatment for many diseases. In this study, we aimed to investigate the function of DMSO on fetal cardiomyocyte proliferation. By tracing BrdU(+)/alpha actinin(+) cells or Ki67(+)/alpha actlinin(+) cells with immunohistochemical staining, we found that DMSO remarkably promoted fetal cardiomyocytes proliferation, and at the late developmental stage (LDS), such effects were more efficient than that at early developmental stage (EDS). Western blot data revealed a significant increase in STAT3 phosphorylation under DMSO treatments at LDS, while not at EDS. Consistently, STAT3 phosphorylation blocker STA21 could greatly reverse DMSO's function at LDS whereas hardly at EDS. Moreover, hearts at the EDS had less total STAT3 protein, but relatively much higher level of phosphorylated STAT3. This suggests that DMSO promote fetal cardiomyocytes proliferation, and STAT3 phosphorylation play a pivotal role in DMSO's function. With maturation, DMSO exerted a better ability to favor cardiomyocyte proliferation depending on STAT3 phosphorylation. Therefore. DMSO could serve as an effective, economic, and safe therapy for heart diseases with cell loss.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hu, Haitao UNSPECIFIED UNSPECIFIED UNSPECIFIED Xue, Jin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Renshun UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yanan UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Chunyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Hongjian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Huamin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-155245
DOI:	10.1536/ihj.18-206
Journal or Publication Title:	Int. Heart J.
Volume:	60
Number:	2
Page Range:	S. 392 - 400
Date:	2019
Publisher:	INT HEART JOURNAL ASSOC
Place of Publication:	TOKYO
ISSN:	1349-3299
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIMETHYL-SULFOXIDE; INDUCED INJURY; HEART GROWTH; CELLS; DIFFERENTIATION; REGENERATION; PATHWAY; TARGET; CANCER Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15524